Exploiting the role of T cells in the pathogenesis of Sjogren's syndrome for therapeutic treatment

被引：20

作者：

An, Qi ^{[1
]}

Zhao, Jingwen ^{[1
]}

Zhu, Xueqing ^{[1
]}

Yang, Baoqi ^{[1
]}

Wu, Zewen ^{[1
]}

Su, Yazhen ^{[1
]}

Zhang, Liyun ^{[1
]}

Xu, Ke ^{[1
]}

Ma, Dan ^{[1
]}

机构：

[1] Shanxi Med Univ, Hosp 3, Shanxi Bethune Hosp, Tongji Shanxi Hosp,Shanxi Acad Med Sci, Taiyuan, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

基金：

中国国家自然科学基金;

关键词：

T cells; Sjogren's syndrome; autoimmune; cytokines; T-cell treatment; DIABETIC MOUSE MODEL; PERIPHERAL-BLOOD; SALIVARY-GLANDS; RECEPTOR EXPRESSION; LYMPHOCYTES; DISEASE; SUBSET; INTERLEUKIN-9; AUTOIMMUNITY; DEFICIENCY;

D O I：

10.3389/fimmu.2022.995895

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sjogrens syndrome (SS) is caused by autoantibodies that attack proprioceptive salivary and lacrimal gland tissues. Damage to the glands leads to dry mouth and eyes and affects multiple systems and organs. In severe cases, SS is life-threatening because it can lead to interstitial lung disease, renal insufficiency, and lymphoma. Histological examination of the labial minor salivary glands of patients with SS reveals focal lymphocyte aggregation of T and B cells. More studies have been conducted on the role of B cells in the pathogenesis of SS, whereas the role of T cells has only recently attracted the attention of researchers. This review focusses on the role of various populations of T cells in the pathogenesis of SS and the progress made in research to therapeutically targeting T cells for the treatment of patients with SS.

引用

页数：15

共 139 条

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