Epidemiology and Outcome of Sepsis in a Tertiary Care PICU of Pakistan

被引:38
作者
Khan, Muhammad Rehan [1 ]
Maheshwari, Prem Kumar [1 ]
Masood, Komal [1 ]
Qamar, Farah Naz [1 ]
Anwar-ul Haque [1 ]
机构
[1] Aga Khan Univ Hosp, Dept Pediat & Child Hlth, Karachi 74800, Pakistan
关键词
Sepsis; Septic shock; Tertiary care; Pediatric intensive care; Pakistan; SEPTIC SHOCK; HEMODYNAMIC SUPPORT; CHILDREN; MORTALITY; GUIDELINES; MANAGEMENT; UNIT;
D O I
10.1007/s12098-012-0706-z
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective To determine the epidemiology and outcome of sepsis in children admitted in pediatric intensive care unit (PICU) of a tertiary care hospital. Methods Retrospective review of children 1 mo to 14 y old, admitted to the PICU with severe sepsis or septic shock from January 2007 through December 2008 was done. Demographic, clinical and laboratory features of subjects were reviewed. The primary outcome was mortality at the time of discharge from PICU. The independent predictors of mortality were modeled using multiple logistic regression. Results In 2 years, 17.3% (133/767) children admitted to the PICU had sepsis. Median age was 18 mo (IQR 6-93 mo), with male: female ratio of 1.6:1. Mean PRISM III score was 9 (+/- 7.8). One third had culture proven infection, majority (20%) having bloodstream infection. The frequency of multi-organ dysfunction syndrome (MODS) was 81% (108/133). The case specific mortality rate of sepsis was 24% (32/133). Multi-organ dysfunction (Adjusted OR 18.0, 95% CI 2.2-144), prism score of > 10 (Adjusted OR 1.5, 95% CI 0.6-4.0) and the need for > 2 inotropes (Adjusted OR 3.5, 95% CI 1.3-9.2) were independently associated with mortality due to sepsis. Conclusions The presence of septic shock and MODS is associated with high mortality in the PICU of developing countries.
引用
收藏
页码:1454 / 1458
页数:5
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