Fatal methanol poisoning: features of liver histopathology

被引：11

作者：

Akhgari, Maryam ^{[1
]}

Panahianpour, Mohammad Hadi ^{[2
]}

Bazmi, Elham ^{[1
]}

Etemadi-Aleagha, Afshar ^{[3
]}

Mandavi, Amirhosein ^{[4
]}

Nazari, Saeed Hashemi ^{[4
]}

机构：

[1] Legal Med Res Ctr, Dept Forens Toxicol, Tehran 11144, Iran

[2] Legal Med Res Ctr, Dept Forens Pathol, Tehran 11144, Iran

[3] Univ Tehran Med Sci, Fac Med, Amir Alam Hosp, Tehran, Iran

[4] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Tehran, Iran

来源：

TOXICOLOGY AND INDUSTRIAL HEALTH | 2013年 / 29卷 / 02期

关键词：

Methanol; forensic pathology; forensic toxicology; liver histopathology; INHALATION TOXICITY; INTOXICATION; ALCOHOL; ACID; RATS;

D O I：

10.1177/0748233711427050

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Methanol poisoning has become a considerable problem in Iran. Liver can show some features of poisoning after methanol ingestion. Therefore, our concern was to examine liver tissue histopathology in fatal methanol poisoning cases in Iranian population. In this study, 44 cases of fatal methanol poisoning were identified in a year. The histological changes of the liver were reviewed. The most striking features of liver damage by light microscopy were micro-vesicular steatosis, macro-vesicular steatosis, focal hepatocyte necrosis, mild intra-hepatocyte bile stasis, feathery degeneration and hydropic degeneration. Blood and vitreous humor methanol concentrations were examined to confirm the proposed history of methanol poisoning. The majority of cases were men (86.36%). In conclusion, methanol poisoning can cause histological changes in liver tissues. Most importantly in cases with mean blood and vitreous humor methanol levels greater than 127 +/- 38.9 mg/dL more than one pathologic features were detected.

引用

页码：136 / 141

页数：6

共 29 条

[1] Fatal methanol intoxication with different survival times - Morphological findings and postmortem methanol distribution [J].

Andresen, H. ;

Schmoldt, H. ;

Matschke, J. ;

Flachskampf, F. A. ;

Turk, E. E. .

FORENSIC SCIENCE INTERNATIONAL, 2008, 179 (2-3) :206-210

[2]

[Anonymous], 2007, Robbins Basic Pathology

[3] Oxidants and antioxidants in alcohol-induced liver disease [J].

Arteel, GE .

GASTROENTEROLOGY, 2003, 124 (03) :778-790

[4]

Azmak Derya, 2006, Legal Medicine, V8, P39, DOI 10.1016/j.legalmed.2005.07.002

[5] Rat liver microsomal and nuclear activation of methanol to hydroxymethyl free radicals [J].

Castro, GD ;

Costantini, MH ;

de Layño, AMAD ;

Castro, JA .

TOXICOLOGY LETTERS, 2002, 129 (03) :227-236

[6] Alcohol and aldehyde dehydrogenase activity measured with fluorogenic substrates in the liver of rats poisoned with methanol [J].

Chrostek, L ;

Szmitkowski, M ;

Jelski, W .

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 2001, 53 (01) :77-80

[7] In vitro effect of methanol on folate-deficient rat hepatocytes [J].

Datta, NJ ;

Namasivayam, A .

DRUG AND ALCOHOL DEPENDENCE, 2003, 71 (01) :87-91

[8] Usefulness of Systematic Histological Examination in Routine Forensic Autopsy [J].

de la Grandmaison, Geoffroy Lorin ;

Charlier, Philippe ;

Durigon, Michel .

JOURNAL OF FORENSIC SCIENCES, 2010, 55 (01) :85-88

[9] Accidental methanol ingestion: case report. [J].

Epker J.L. ;

Bakker J. .

BMC Emergency Medicine, 10 (1) :3

[10]

Hantson Ph E, 2006, Bull Mem Acad R Med Belg, V161, P425

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