Leptin as a link between the immune system and kidney-related diseases: leading actor or just a coadjuvant?

被引：22
作者：
Moraes-Vieira, P. M. M. [1 ]
Bassi, E. J. [1 ]
Araujo, R. C. [2 ]
Camara, N. O. S. [1 ]
机构：
[1] Univ Sao Paulo, Dept Immunol, Inst Biomed Sci, BR-05508900 Sao Paulo, Brazil
[2] Univ Fed Sao Paulo, Dept Biophys, Sao Paulo, Brazil
来源：
OBESITY REVIEWS | 2012年 / 13卷 / 08期
基金：
巴西圣保罗研究基金会;
关键词：
Foxp3; kidney; leptin; nephrology; CHRONIC-HEMODIALYSIS PATIENTS; CHRONIC-RENAL-FAILURE; HUMAN DENDRITIC CELLS; REGULATORY T-CELLS; BODY-MASS INDEX; INSULIN-RESISTANCE; PLASMA LEPTIN; PROINFLAMMATORY CYTOKINES; DIABETIC-NEPHROPATHY; MULTIPLE-SCLEROSIS;
D O I：
10.1111/j.1467-789X.2012.00997.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Food intake and nutritional status modify the physiological responses of the immune system to illness and infection and regulate the development of chronic inflammatory processes, such as kidney disease. Adipose tissue secretes immune-related proteins called adipokines that have pleiotropic effects on both the immune and neuroendocrine systems, linking metabolism and immune physiology. Leptin, an adipose tissue-derived adipokine, displays a variety of immune and physiological functions, and participates in several immune responses. Here, we review the current literature on the role of leptin in kidney diseases, linking adipose tissue and the immune system with kidney-related disorders. The modulation of this adipose hormone may have a major impact on the treatment of several immune- and metabolic-related kidney diseases.
引用
收藏
页码：733 / 743
页数：11
相关论文
共 100 条
[91]   Body mass index and fat mass are the primary correlates of insulin resistance in nondiabetic stage 3-4 chronic kidney disease patients [J].
Trirogoff, M. Luisa ;
Shintani, Ayumi ;
Himmelfarb, Jonathan ;
Ikizler, T. Alp .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2007, 86 (06) :1642-1648
[92]   CNS Leptin Action Modulates Immune Response and Survival in Sepsis [J].
Tschoep, Johannes ;
Nogueiras, Ruben ;
Haas-Lockie, Sarah ;
Kasten, Kevin R. ;
Castaneda, Tamara R. ;
Huber, Nadine ;
Guanciale, Kelsey ;
Perez-Tilve, Diego ;
Habegger, Kirk ;
Ottaway, Nickki ;
Woods, Stephen C. ;
Oldfield, Brian ;
Clarke, Iain ;
Chua, Streamson, Jr. ;
Farooqi, I. Sadaf ;
O'Rahilly, Stephen ;
Caldwell, Charles C. ;
Tschoep, Matthias H. .
JOURNAL OF NEUROSCIENCE, 2010, 30 (17) :6036-6047
[93]   A novel leptin receptor isoform in rat [J].
Wang, MY ;
Zhou, YT ;
Newgard, CB ;
Unger, RH .
FEBS LETTERS, 1996, 392 (02) :87-90
[94]  
Whaley-Connell A, 2006, J CARDIOMETAB SYNDR, V1, P15
[95]  
Whaley-Connell Adam, 2006, J Cardiometab Syndr, V1, P209, DOI 10.1111/j.1559-4564.2006.05631.x
[96]   FASTING-ENHANCED IMMUNE EFFECTOR MECHANISMS IN OBESE SUBJECTS [J].
WING, EJ ;
STANKO, RT ;
WINKELSTEIN, A ;
ADIBI, SA .
AMERICAN JOURNAL OF MEDICINE, 1983, 75 (01) :91-96
[97]   Leptin stimulates proliferation and TGF-β expression in renal glomerular endothelial cells:: Potential role in glomerulosclerosis [J].
Wolf, G ;
Hamann, A ;
Han, DC ;
Helmchen, U ;
Thaiss, F ;
Ziyadeh, FN ;
Stahl, RAK .
KIDNEY INTERNATIONAL, 1999, 56 (03) :860-872
[98]   Leptin indirectly activates human neutrophils via induction of TNF-α [J].
Zarkesh-Esfahani, H ;
Pockley, AG ;
Wu, ZD ;
Hellewell, PG ;
Weetman, AP ;
Ross, RJM .
JOURNAL OF IMMUNOLOGY, 2004, 172 (03) :1809-1814
[99]   POSITIONAL CLONING OF THE MOUSE OBESE GENE AND ITS HUMAN HOMOLOG [J].
ZHANG, YY ;
PROENCA, R ;
MAFFEI, M ;
BARONE, M ;
LEOPOLD, L ;
FRIEDMAN, JM .
NATURE, 1994, 372 (6505) :425-432
[100]   Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines [J].
Zhao, YR ;
Sun, R ;
You, L ;
Gao, CY ;
Tian, ZG .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 300 (02) :247-252
12345678910