Leptin as a link between the immune system and kidney-related diseases: leading actor or just a coadjuvant?

被引：22

作者：

Moraes-Vieira, P. M. M. ^{[1
]}

Bassi, E. J. ^{[1
]}

Araujo, R. C. ^{[2
]}

Camara, N. O. S. ^{[1
]}

机构：

[1] Univ Sao Paulo, Dept Immunol, Inst Biomed Sci, BR-05508900 Sao Paulo, Brazil

[2] Univ Fed Sao Paulo, Dept Biophys, Sao Paulo, Brazil

来源：

OBESITY REVIEWS | 2012年 / 13卷 / 08期

基金：

巴西圣保罗研究基金会;

关键词：

Foxp3; kidney; leptin; nephrology; CHRONIC-HEMODIALYSIS PATIENTS; CHRONIC-RENAL-FAILURE; HUMAN DENDRITIC CELLS; REGULATORY T-CELLS; BODY-MASS INDEX; INSULIN-RESISTANCE; PLASMA LEPTIN; PROINFLAMMATORY CYTOKINES; DIABETIC-NEPHROPATHY; MULTIPLE-SCLEROSIS;

D O I：

10.1111/j.1467-789X.2012.00997.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Food intake and nutritional status modify the physiological responses of the immune system to illness and infection and regulate the development of chronic inflammatory processes, such as kidney disease. Adipose tissue secretes immune-related proteins called adipokines that have pleiotropic effects on both the immune and neuroendocrine systems, linking metabolism and immune physiology. Leptin, an adipose tissue-derived adipokine, displays a variety of immune and physiological functions, and participates in several immune responses. Here, we review the current literature on the role of leptin in kidney diseases, linking adipose tissue and the immune system with kidney-related disorders. The modulation of this adipose hormone may have a major impact on the treatment of several immune- and metabolic-related kidney diseases.

引用

页码：733 / 743

页数：11

共 100 条

[1] Pathophysiological role of leptin in obesity-related hypertension [J].

Aizawa-Abe, M ;

Ogawa, Y ;

Masuzaki, H ;

Ebihara, K ;

Satoh, N ;

Iwai, H ;

Matsuoka, N ;

Hayashi, T ;

Hosoda, K ;

Inoue, G ;

Yoshimasa, Y ;

Nakao, K .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (09) :1243-1252

[2]

Bastard JP, 2006, EUR CYTOKINE NETW, V17, P4

[3] Leptin: A Critical Regulator of CD4+ T-cell Polarization in Vitro and in Vivo [J].

Batra, Arvind ;

Okur, Besir ;

Glauben, Rainer ;

Erben, Ulrike ;

Ihbe, Jakob ;

Stroh, Thorsten ;

Fedke, Inka ;

Chang, Hyun-Dong ;

Zeitz, Martin ;

Siegmund, Britta .

ENDOCRINOLOGY, 2010, 151 (01) :56-62

[4] Longitudinal study of leptin levels in chronic hemodialysis patients [J].

Beberashvili, Ilia ;

Sinuani, Inna ;

Azar, Ada ;

Yasur, Hila ;

Feldman, Leonid ;

Averbukh, Zhan ;

Weissgarten, Joshua .

NUTRITION JOURNAL, 2011, 10

[5] The body mass index paradox and an obesity, inflammation, and atherosclerosis syndrome in chronic kidney disease [J].

Beddhu, S .

SEMINARS IN DIALYSIS, 2004, 17 (03) :229-232

[6] Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis [J].

Busso, N ;

So, A ;

Chobaz-Péclat, V ;

Morard, C ;

Martinez-Soria, E ;

Talabot-Ayer, D ;

Gabay, C .

JOURNAL OF IMMUNOLOGY, 2002, 168 (02) :875-882

[7] Leptin regulates functional capacities of polymorphonuclear neutrophils [J].

Caldefie-Chezet, F ;

Poulin, A ;

Vasson, MP .

FREE RADICAL RESEARCH, 2003, 37 (08) :809-814

[8]

Caldefie-Chezet F, 2001, J LEUKOCYTE BIOL, V69, P414

[9] Chronic cardiovascular and renal actions of leptin - Role of adrenergic activity [J].

Carlyle, M ;

Jones, OB ;

Kuo, JJ ;

Hall, JE .

HYPERTENSION, 2002, 39 (02) :496-501

[10] IMMUNOCOMPETENCE IN OBESITY [J].

CHANDRA, RK ;

KUTTY, KM .

ACTA PAEDIATRICA SCANDINAVICA, 1980, 69 (01) :25-30

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