Catalytic enantioselective Michael addition in the synthesis of α-aminophosphonates

被引：39

作者：

Jászay, ZM

Németh, G

Pham, TS

Petneházy, I

Grün, A

Toke, L

机构：

[1] Hungarian Acad Sci, Organ Chem Technol Res Grp, H-1521 Budapest, Hungary

[2] Budapest Univ Technol & Econ, Dept Organ Chem Technol, H-1521 Budapest, Hungary

来源：

TETRAHEDRON-ASYMMETRY | 2005年 / 16卷 / 23期

基金：

匈牙利科学研究基金会;

关键词：

D O I：

10.1016/j.tetasy.2005.10.020

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Enantioenriched (S)-phosphoglutaminic acid derivatives with up to 72% ee were obtained in the catalytic enantioselective Michael reaction of the achiral phosphoglycine synthon. The scope and limitation of the process in terms of the catalyst (diverse (R,R)-TADDOL derivatives) and the base (solid alkali metal tert-butoxides) were examined. The nature of the transition complex was also investigated. ((c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3837 / 3840

页数：4

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