Synthesis of Novel 1,2,3-Triazole-dihydro[3,2-c]chromenones as Acetylcholinesterase Inhibitors

被引：31

作者：

Saeedi, Mina ^{[1
,2
]}

Ansari, Shirin ^{[3
,4
]}

Mahdavi, Mohammad ^{[3
,4
]}

Sabourian, Reyhaneh ^{[2
]}

Akbarzadeh, Tahmineh ^{[2
,3
,4
]}

Foroumadi, Alireza ^{[3
,4
]}

Shafiee, Abbas ^{[3
,4
]}

机构：

[1] Univ Tehran Med Sci, Med Plants Res Ctr, Fac Pharm, Tehran, Iran

[2] Univ Tehran Med Sci, Persian Med & Pharm Res Ctr, Tehran, Iran

[3] Univ Tehran Med Sci, Fac Pharm, Dept Med Chem, Tehran, Iran

[4] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Tehran, Iran

来源：

SYNTHETIC COMMUNICATIONS | 2015年 / 45卷 / 20期

基金：

美国国家科学基金会;

关键词：

Acetylcholinesterase; heterocycles; 1; 2; 3-triazole-dihydro[3; 2-c]chromenones; COUMARIN DERIVATIVES; ALZHEIMERS-DISEASE; BIOLOGICAL EVALUATION; EFFICIENT SYNTHESIS; CLICK CHEMISTRY; 1,2,3-TRIAZOLE DERIVATIVES; B INHIBITORS; ONE-POT; DESIGN; AGGREGATION;

D O I：

10.1080/00397911.2015.1077971

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel series of 1,2,3-triazole-dihydro[3,2-c]chromenone derivatives were synthesized through an efficient three-step reaction starting from 4-hydroxybenzaldehyde. All the newly synthesized compounds were characterized by infrared and NMR spectroscopy as well as elemental analysis and evaluated for their acetylcholinesterase inhibitory activity.

引用

收藏

页码：2311 / 2318

页数：8

相关论文

共 57 条

[1] Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1 [J].

Akselsen, Oyvind W. ;

Odlo, Kristin ;

Cheng, Jing-Jy ;

Maccari, Giorgio ;

Botta, Maurizio ;

Hansen, Trond Vidar .

BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (01) :234-242

[2] Synthesis of some novel pyrano[2,3-f]chromenone derivatives [J].

Alizadeh, Babak Heidary ;

Saeedi, Mina ;

Dehghan, Gholamreza ;

Foroumadi, Alireza ;

Shafiee, Abbas .

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2015, 12 (04) :605-612

[3] 1,2,3-TRIAZOLE-[2',5'-BIS-O-(TERT-BUTYLDIMETHYLSILYL)-BETA-D-RIBOFURANOSYL]-3'-SPIRO-5''-(4''-AMINO-1'',2''-OXATHIOL 2'',2''-DIOXIDE) (TSAO) ANALOGS - SYNTHESIS AND ANTI-HIV-1 ACTIVITY [J].

ALVAREZ, R ;

VELAZQUEZ, S ;

SANFELIX, A ;

AQUARO, S ;

DECLERCQ, E ;

PERNO, CF ;

KARLSSON, A ;

BALZARINI, J ;

CAMARASA, MJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (24) :4185-4194

[4] A review on coumarins as acetylcholinesterase inhibitors for Alzheimer's disease [J].

Anand, Preet ;

Singh, Baldev ;

Singh, Nirmal .

BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (03) :1175-1180

[5] Convenient and sequential one-pot route for synthesis of 2-thioxoquinazolinone and quinazolinobenzothiazinedione derivatives [J].

Asadi, Mehdi ;

Masoomi, Shiva ;

Ebrahimi, Seyed Mostafa ;

Mahdavi, Mohammad ;

Saeedi, Mina ;

Shafiee, Abbas ;

Foroumadi, Alireza .

MONATSHEFTE FUR CHEMIE, 2014, 145 (03) :497-504

[6] Evolution in the conceptualization of dementia and Alzheimer's disease: Greco-Roman period to the 1960s [J].

Berchtold, NC ;

Cotman, CW .

NEUROBIOLOGY OF AGING, 1998, 19 (03) :173-189

[7] Novel 1,2,3-Triazole Derivatives for Use against Mycobacterium tuberculosis H37Rv (ATCC 27294) Strain [J].

Boechat, Nubia ;

Ferreira, Vitor F. ;

Ferreira, Sabrina B. ;

Ferreira, Maria de Lourdes G. ;

da Silva, Fernando de C. ;

Bastos, Monica M. ;

Costa, Marilia dos S. ;

Lourenco, Maria Cristina S. ;

Pinto, Angelo C. ;

Krettli, Antoniana U. ;

Aguiar, Anna Caroline ;

Teixeira, Brunno M. ;

da Silva, Nathalia V. ;

Martins, Priscila R. C. ;

Bezerra, Flavio Augusto F. M. ;

Camilo, Ane Louise S. ;

da Silva, Gerson P. ;

Costa, Carolina C. P. .

JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (17) :5988-5999

[8] Multi-target-directed drug design strategy: From a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease [J].

Bolognesi, Maria Laura ;

Cavalli, Andrea ;

Valgimigli, Luca ;

Bartolini, Manuela ;

Rosini, Michela ;

Andrisano, Vincenza ;

Recanatini, Maurizio ;

Melchiorre, Carlo .

JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (26) :6446-6449

[9] Design, Synthesis, and in Vitro Biological Evaluation of 1H-1,2,3-Triazole-4-carboxamide Derivatives as New Anti-influenza A Agents Targeting Virus Nucleoprotein [J].

Cheng, Huimin ;

Wan, Junting ;

Lin, Meng-I ;

Liu, Yingxue ;

Lu, Xiaoyun ;

Liu, Jinsong ;

Xu, Yong ;

Chen, Jianxin ;

Tu, Zhengchao ;

Cheng, Yih-Shyun E. ;

Ding, Ke .

JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (05) :2144-2153

[10]

Choure R., 2010, CAN J CHEM ENG TECHN, V1, P7, DOI DOI 10.1111/CBDD.12609

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