Long-term cellular immune response in immunocompromised unvaccinated COVID-19 patients undergoing monoclonal antibody treatment

被引：2

作者：

Thuemmler, Laura ^{[1
,2
]}

Konik, Margarethe ^{[1
]}

Lindemann, Monika ^{[2
]}

Fisenkci, Neslinur ^{[2
]}

Koldehoff, Michael ^{[3
,4
]}

Gaeckler, Anja ^{[5
]}

Horn, Peter A. ^{[2
]}

Theodoropoulos, Fotis ^{[6
]}

Taube, Christian ^{[6
]}

Zettler, Markus ^{[1
]}

Anastasiou, Olympia Evdoxia ^{[7
]}

Brass, Peer ^{[1
]}

Jansen, Sarah ^{[1
]}

Witzke, Oliver ^{[1
]}

Rohn, Hana ^{[1
]}

Krawczyk, Adalbert ^{[1
,7
]}

机构：

[1] Univ Duisburg Essen, Univ Med Essen, Univ Hosp Essen, West German Ctr Infect Dis,Dept Infect Dis, Essen, Germany

[2] Univ Duisburg Essen, Univ Med Essen, Univ Hosp Essen, Inst Transfus Med, Essen, Germany

[3] Univ Duisburg Essen, Univ Med Essen, Univ Hosp Essen, Dept Hematol & Stem Cell Transplantat, Essen, Germany

[4] Univ Duisburg Essen, Univ Med Essen, Univ Hosp Essen, Dept Hyg & Environm Med, Essen, Germany

[5] Univ Duisburg Essen, Univ Med Essen, Univ Hosp Essen, Dept Nephrol, Essen, Germany

[6] Univ Duisburg Essen, Univ Med Essen Ruhrlandklin, Dept Pneumol, Essen, Germany

[7] Univ Duisburg Essen, Univ Med Essen, Univ Hosp Essen, Inst Virol, Essen, Germany

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

关键词：

COVID-19; immunosuppression; SARS-CoV-2; monoclonal antibody treatment; cellular immune response; SARS-COV-2; KIDNEY;

D O I：

10.3389/fimmu.2022.980698

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunocompromised patients are at increased risk for a severe course of COVID-19. Treatment of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection with anti-SARS-CoV-2 monoclonal antibodies (mAbs) has become widely accepted. However, the effects of mAb treatment on the long-term primary cellular response to SARS-CoV-2 are unknown. In the following study, we investigated the long-term cellular immune responses to SARS-CoV-2 Spike S1, Membrane (M) and Nucleocapsid (N) antigens using the ELISpot assay in unvaccinated, mAb-treated immunocompromised high-risk patients. Anti-SARS-CoV-2 mAb untreated though vaccinated COVID-19 immunocompromised patients, vaccinated SARS-CoV-2 immunocompromised patients without COVID-19 and vaccinated healthy control subjects served as control groups. The cellular immune response was determined at a median of 5 months after SARS-CoV-2 infection. Our data suggest that immunocompromised patients develop an endogenous long-term cellular immune response after COVID-19, although at low levels. A better understanding of the cellular immune response will help guide clinical decision making for these vulnerable patient cohorts.

引用

页数：7

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