A Practical Protocol for the Conjugation of Various Amino Acids to Protoporphyrin IX

被引：7

作者：

Maximova, Ksenia ^{[1
]}

Pisarek, Sabina ^{[1
]}

Gryko, Dorota ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Organ Chem, PL-01224 Warsaw, Poland

来源：

SYNTHESIS-STUTTGART | 2013年 / 45卷 / 08期

关键词：

porphyrins; amides; amino acids; peptides; esters; hydrolysis; SOLUBLE GUANYLATE-CYCLASE; PHOTODYNAMIC THERAPY; AMIDE-BOND; PEPTIDE; DERIVATIVES; NAPHTHALENE; HEME;

D O I：

10.1055/s-0032-1318486

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An effective and reliable method was developed for the synthesis of protoporphyrin IX-derived amides. The reaction of protoporphyrin IX with an amino acid [L-leucine, L-valine, L-lysine, L-aspartic acid (Asp), L-glutamic acid (Glu), glycine, or 6-aminohexanoic acid] or a short peptide (Asp-Glu) as an amine counterpart in the presence of O-(benzotriazol-1-yl)-N,N,N ',N '- etramethyluronium hexafluorophosphate and 1H-1,2,3-benzotriazol-1-ol gave the desired diamides in excellent yields.

引用

页码：1099 / 1105

页数：7

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