Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells

被引：188

作者：

Bermejo, Daniela A. ^{[1
]}

Jackson, Shaun W. ^{[2
,3
]}

Gorosito-Serran, Melisa ^{[1
]}

Acosta-Rodriguez, Eva V. ^{[1
]}

Amezcua-Vesely, Maria C. ^{[1
]}

Sather, Blythe D. ^{[2
,3
]}

Singh, Akhilesh K. ^{[2
,3
]}

Khim, Socheath ^{[2
,3
]}

Mucci, Juan ^{[4
]}

Liggitt, Denny ^{[5
]}

Campetella, Oscar ^{[4
]}

Oukka, Mohamed ^{[2
,3
,6
]}

Gruppi, Adriana ^{[1
]}

Rawlings, David J. ^{[2
,3
,6
]}

机构：

[1] Univ Nacl Cordoba, Consejo Nacl Invest Cient & Tecn, Fac Ciencias Quim, Ctr Invest Bioquim Clin & Inmunol, RA-5000 Cordoba, Argentina

[2] Univ Washington, Sch Med, Dept Pediat, Seattle, WA 98195 USA

[3] Seattle Childrens Res Inst, Seattle, WA USA

[4] Univ Nacl San Martin, Inst Invest Biotecnol, San Martin, Argentina

[5] Univ Washington, Sch Med, Dept Comparat Med, Seattle, WA 98195 USA

[6] Univ Washington, Sch Med, Dept Immunol, Seattle, WA USA

来源：

NATURE IMMUNOLOGY | 2013年 / 14卷 / 05期

基金：

美国国家卫生研究院;

关键词：

CAMPYLOBACTER-JEJUNI; RECEPTOR; INFECTION; ANTIGEN; DIFFERENTIATION; EXPRESSION; IMMUNITY; SIALYLTRANSFERASE; IDENTIFICATION; GLYCOSYLATION;

D O I：

10.1038/ni.2569

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Here we identified B cells as a major source of rapid, innate-like production of interleukin 17 (IL-17) in vivo in response to infection with Trypanosoma cruzi. IL-17(+) B cells had a plasmablast phenotype, outnumbered cells of the T(H)17 subset of helper T cells and were required for an optimal response to this pathogen. With both mouse and human primary B cells, we found that exposure to parasite-derived trans-sialidase in vitro was sufficient to trigger modification of the cell-surface mucin CD45, which led to signaling dependent on the kinase Btk and production of IL-17A or IL-17F via a transcriptional program independent of the transcription factors ROR gamma t and Ahr. Our combined data suggest that the generation of IL-17(+) B cells may be a previously unappreciated feature of innate immune responses required for pathogen control or IL-17-mediated autoimmunity.

引用

页码：514 / +

页数：11

共 55 条

[1] Galectin-3 mediates IL-4-induced survival and differentiation of B cells:: Functional cross-talk and implications during Trypanosoma cruzi infection [J].