Caffeine effects on systemic metabolism, oxidative-inflammatory pathways, and exercise performance

被引:115
作者
Barcelos, Romulo P. [1 ,2 ]
Lima, Frederico D. [3 ]
Carvalho, Nelson R. [4 ]
Bresciani, Guilherme [5 ]
Royes, Luiz F. F. [1 ,3 ]
机构
[1] Univ Fed Santa Maria UFSM, Ctr Ciencias Nat & Exatas, Dept Bioquim & Biol Mol, Santa Maria, RS, Brazil
[2] Univ Passo Fundo UPF, Programa Posgrad Bioexperimentacao PPGBioexp, Passo Fundo, RS, Brazil
[3] Univ Fed Santa Maria, Ctr Educ Fis & Desportos, Lab Bioquim Exercicio, Santa Maria, RS, Brazil
[4] Inst Fed Farroupilha IFF, Santo Angelo, Brazil
[5] Pontificia Univ Catolica Valparaiso, Escuela Educ Fis, Grp Invest Rendimiento Fis & Salud IRyS, Valparaiso, Chile
关键词
NF-KAPPA-B; TRAUMATIC BRAIN-INJURY; INDUCED CALCIUM-RELEASE; RYANODINE RECEPTOR; SKELETAL-MUSCLE; INTRACELLULAR CALCIUM; REACTIVE OXYGEN; POWER OUTPUT; ANTIOXIDANT ACTIVITY; CYCLING PERFORMANCE;
D O I
10.1016/j.nutres.2020.05.005
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Caffeine, a xanthine alkaloid compound, is consumed widely and daily by humans, as it is present in several regular beverages such as tea, coffee, soda beverages, and some drugs. Its consumption triggers arousal and alertness, improves mood, and causes the release of catecholamines, which induce beneficial effects on human behavior. Nonetheless, caffeine has been related to other beneficial effects such as antioxidant and anti-inflammatory actions that are extremely important to human health, altering the cellular redox and inflammatory status in a dose-dependent manner. Caffeine intake has also shown ergogenic effects, which are attributed to different factors, such as enhanced substrate utilization, fatigue delay, and alertness. As such, caffeine has been consumed by athletes from different sports modalities, with positive and negative effects declared. Although peripheral tissues such as the heart, skeletal muscle, and adipocytes are also impacted, there is a deficit of recognized mechanisms in systemic metabolism when compared to caffeine action in the central nervous system. This review summarizes the most relevant classical and current literature available regarding the use of caffeine in different metabolic situations, such as oxidative and inflammatory status, as well as anaerobic and aerobic physical exercises. Here, we identified the non-central nervous system caffeine mechanisms modulation, as most are still unknown or controversial, highlighting its influence in the peripheral system and its essential and crucial impacts on the human's organism adaptation. (c) 2020 Elsevier Inc. All rights reserved.
引用
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页码:1 / 17
页数:17
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