Anti-inflammatory effects of cordycepin: A review

被引：77

作者：

Tan, Lu ^{[1
]}

Song, Xiaominting ^{[1
]}

Ren, Yali ^{[1
]}

Wang, Miao ^{[1
]}

Guo, Chuanjie ^{[1
]}

Guo, Dale ^{[1
]}

Gu, Yucheng ^{[2
]}

Li, Yuzhi ^{[1
]}

Cao, Zhixing ^{[1
]}

Deng, Yun ^{[1
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Sch Pharm, Natl Key Lab Breeding Base Systemat Res Dev & Uti, Key Lab Standardizat Chinese Herbal Med,Minist Ed, 1166 Liu Tai Ave, Chengdu, Sichuan, Peoples R China

[2] Syngenta Jealotts Hill Int Res Ctr, Bracknell, Berks, England

来源：

PHYTOTHERAPY RESEARCH | 2021年 / 35卷 / 03期

基金：

中国国家自然科学基金;

关键词：

anti-inflammatory; cordycepin; COVID-19; inflammatory diseases; pharmacokinetics; toxicology; ACUTE LUNG INJURY; INTRACEREBRAL HEMORRHAGE; INFLAMMATORY RESPONSES; ADENOSINE RECEPTORS; IN-VITRO; EXPRESSION; 3'-DEOXYADENOSINE; MECHANISMS; INHIBITION; PATHWAY;

D O I：

10.1002/ptr.6890

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cordycepin is the major bioactive component extracted fromCordyceps militaris. In recent years, cordycepin has received increasing attention owing to its multiple pharmacological activities. This study reviews recent researches on the anti-inflammatory effects and the related activities of cordycepin. The results from our review indicate that cordycepin exerts protective effects against inflammatory injury for many diseases including acute lung injury (ALI), asthma, rheumatoid arthritis, Parkinson's disease (PD), hepatitis, atherosclerosis, and atopic dermatitis. Cordycepin regulates the NF-kappa B, RIP2/Caspase-1, Akt/GSK-3 beta/p70S6K, TGF-beta/Smads, and Nrf2/HO-1 signaling pathways among others. Several studies focusing on cordycepin derivatives were reviewed and found to down metabolic velocity of cordycepin and increase its bioavailability. Moreover, cordycepin enhanced immunity, inhibited the proliferation of viral RNA, and suppressed cytokine storms, thereby suggesting its potential to treat COVID-19 and other viral infections. From the collected and reviewed information, this article provides the theoretical basis for the clinical applications of cordycepin and discusses the path for future studies focusing on expanding the medicinal use of cordycepin. Taken together, cordycepin and its analogs show great potential as the next new class of anti-inflammatory agents.

引用

页码：1284 / 1297

页数：14

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