Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice

被引：45

作者：

Fujita, M ^{[1
]}

Ye, Q ^{[1
]}

Ouchi, H ^{[1
]}

Harada, E ^{[1
]}

Inoshima, I ^{[1
]}

Kuwano, K ^{[1
]}

Nakanishi, Y ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Res Inst Dis Chest, Fukuoka 812, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 02期

关键词：

D O I：

10.1128/AAC.50.2.739-743.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity.

引用

页码：739 / 743

页数：5

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