The Ghrelin Axis-Does It Have an Appetite for Cancer Progression?

被引：70

作者：

Chopin, Lisa K.

Seim, Inge

Walpole, Carina M.

Herington, Adrian C.

机构：

[1] Queensland Univ Technol, Ghrelin Res Grp, Inst Hlth & Biomed Innovat, Brisbane, Qld 4001, Australia

[2] Australian Prostate Canc Res Ctr Queensland, Brisbane, Qld 4001, Australia

来源：

ENDOCRINE REVIEWS | 2012年 / 33卷 / 06期

基金：

英国医学研究理事会;

关键词：

GROWTH-HORMONE SECRETAGOGUE; DES-ACYL GHRELIN; ACTIVATED PROTEIN-KINASE; MESSENGER-RNA EXPRESSION; O-ACYLTRANSFERASE GOAT; ISOPROTERENOL-INDUCED LIPOLYSIS; PLASMA OBESTATIN LEVELS; STIMULATES FOOD-INTAKE; PANCREATIC BETA-CELLS; HUMAN PROSTATE-CANCER;

D O I：

10.1210/er.2011-1007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ghrelin, the endogenous ligand for the GH secretagogue receptor (GHSR), is a peptide hormone with diverse physiological roles. Ghrelin regulates GH release, appetite and feeding, gut motility, and energy balance and also has roles in the cardiovascular, immune, and reproductive systems. Ghrelin and the GHSR are expressed in a wide range of normal and tumor tissues, and a fluorescein-labeled, truncated form of ghrelin is showing promise as a biomarker for prostate cancer. Plasma ghrelin levels are generally inversely related to body mass index and are unlikely to be useful as a biomarker for cancer, but may be useful as a marker for cancer cachexia. Some single nucleotide polymorphisms in the ghrelin and GHSR genes have shown associations with cancer risk; however, larger studies are required. Ghrelin regulates processes associated with cancer, including cell proliferation, apoptosis, cell migration, cell invasion, inflammation, andangiogenesis; however, the role of ghrelin in cancer is currently unclear. Ghrelin has predominantly antiinflammatory effects and may play a role in protecting against cancer-related inflammation. Ghrelin and its analogs show promise as treatments for cancer-related cachexia. Further studies using in vivo models are required to determine whether ghrelin has a role in cancer progression. (Endocrine Reviews 33: 849-891, 2012)

引用

页码：849 / 891

页数：43

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