Toluene derivatives as simple coupling precursors for cascade palladium-catalyzed oxidative C-H bond acylation of acetanilides

被引：149

作者：

Wu, Yinuo ^{[1
,2
]}

Choy, Pui Ying ^{[1
,2
]}

Mao, Fei ^{[3
]}

Kwong, Fuk Yee ^{[1
,2
]}

机构：

[1] Hong Kong Polytech Univ, State Key Lab Chirosci, Kowloon, Hong Kong, Peoples R China

[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China

[3] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 07期

关键词：

TERT-BUTYL HYDROPEROXIDE; ALDEHYDES; COMPLEXES; CHEMISTRY; ARYLATION; ANILIDES; ACTIVATION; QUINOLINE; HALIDES; ACCESS;

D O I：

10.1039/c2cc37352a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A palladium-catalyzed cascade cross-coupling of acetanilide and toluene for the synthesis of ortho-acylacetanilide is described. Toluene derivatives can act as effective acyl precursors (upon sp(3)-C-H bond oxidation by a Pd/TBHP system) in the oxidative coupling between two C-H bonds. This dehydrogenative Pd-catalyzed ortho-acylation proceeds under mild reaction conditions.

引用

页码：689 / 691

页数：3

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