MicroRNA miR-155 Affects Antiviral Effector and Effector Memory CD8 T Cell Differentiation

被引：63

作者：

Tsai, Ching-Yi ^{[1
]}

Allie, S. Rameeza ^{[1
]}

Zhang, Weijun ^{[1
]}

Usherwood, Edward J. ^{[1
]}

机构：

[1] Dartmouth Coll, Geisel Sch Med, Dept Microbiol & Immunol, Lebanon, NH 03756 USA

来源：

JOURNAL OF VIROLOGY | 2013年 / 87卷 / 04期

关键词：

IN-VIVO; ACTIVATION; INFECTION; SUBSETS; PATHWAY;

D O I：

10.1128/JVI.01742-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

MicroRNAs are key regulators of the immune response, but their role in CD8 T cell differentiation in vivo is not known. We show that miR-155 is important in both effector and memory antiviral CD8 T cell responses. Without miR-155, there was a weaker effector response and a skewing toward memory precursor cells. At the memory stage, miR-155-deficient CD8 T cells preferentially differentiated into central memory cells and were capable of mounting a potent secondary response.

引用

页码：2348 / 2351

页数：4

共 15 条

[1] Programmed Death 1 Regulates Development of Central Memory CD8 T Cells after Acute Viral Infection [J].

Allie, S. Rameeza ;

Zhang, Weijun ;

Fuse, Shinchiro ;

Usherwood, Edward J. .

JOURNAL OF IMMUNOLOGY, 2011, 186 (11) :6280-6286

[2] Selected MicroRNAs Define Cell Fate Determination of Murine Central Memory CD8 T Cells [J].

Almanza, Gonzalo ;

Fernandez, Antonio ;

Volinia, Stefano ;

Cortez-Gonzalez, Xochitl ;

Croce, Carlo M. ;

Zanetti, Maurizio .

PLOS ONE, 2010, 5 (06)

[3] MicroRNAs: new regulators of immune cell development and function [J].

Baltimore, David ;

Boldin, Mark P. ;

O'Connell, Ryan M. ;

Rao, Dinesh S. ;

Taganov, Konstantin D. .

NATURE IMMUNOLOGY, 2008, 9 (08) :839-845

[4] An Interleukin-21-Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells [J].

Cui, Weiguo ;

Liu, Ying ;

Weinstein, Jason S. ;

Craft, Joseph ;

Kaech, Susan M. .

IMMUNITY, 2011, 35 (05) :792-805

[5] Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation [J].

Forrest, A. R. R. ;

Kanamori-Katayama, M. ;

Tomaru, Y. ;

Lassmann, T. ;

Ninomiya, N. ;

Takahashi, Y. ;

de Hoon, M. J. L. ;

Kubosaki, A. ;

Kaiho, A. ;

Suzuki, M. ;

Yasuda, J. ;

Kawai, J. ;

Hayashizaki, Y. ;

Hume, D. A. ;

Suzuki, H. .

LEUKEMIA, 2010, 24 (02) :460-466

[6] MicroRNA-155 Regulates Inflammatory Cytokine Production in Tumor-associated Macrophages via Targeting C/EBPβ [J].

He, Min ;

Xu, Zhenqun ;

Ding, Tong ;

Kuang, Dong-Ming ;

Zheng, Limin .

CELLULAR & MOLECULAR IMMUNOLOGY, 2009, 6 (05) :343-352

[7] miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27kip1, KPC1, and SOCS-1 [J].

Lu, Changming ;

Huang, Xin ;

Zhang, Xiaoxiao ;

Roensch, Kristin ;

Cao, Qing ;

Nakayama, Keiichi I. ;

Blazar, Bruce R. ;

Zeng, Yan ;

Zhou, Xianzheng .

BLOOD, 2011, 117 (16) :4293-4303

[8] MicroRNA-21 Limits In Vivo Immune Response-Mediated Activation of the IL-12/IFN-γ Pathway, Th1 Polarization, and the Severity of Delayed-Type Hypersensitivity [J].

Lu, Thomas X. ;

Hartner, Jochen ;

Lim, Eun-Jin ;

Fabry, Victoria ;

Mingler, Melissa K. ;

Cole, Eric T. ;

Orkin, Stuart H. ;

Aronow, Bruce J. ;

Rothenberg, Marc E. .

JOURNAL OF IMMUNOLOGY, 2011, 187 (06) :3362-3373

[9]

Manjunath N, 2001, J CLIN INVEST, V108, P871, DOI 10.1172/JCI13296

[10] Different functional capacities of latent and lytic antigen-specific CD8 T cells in murine gammaherpesvirus infection [J].

Obar, JJ ;

Crist, SG ;

Gondek, DC ;

Usherwood, EJ .

JOURNAL OF IMMUNOLOGY, 2004, 172 (02) :1213-1219

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