Towards achieving a flattop crystal size distribution by continuous seeding and controlled growth

被引：39

作者：

Jiang, Mo ^{[1
,2
]}

Wong, Min Hao ^{[2
]}

Zhu, Zhilong ^{[1
,2
]}

Zhang, Jieqian ^{[2
]}

Zhou, Lifang ^{[1
,2
]}

Wang, Ke ^{[2
]}

Versypt, Ashlee N. Ford ^{[2
]}

Si, Tong ^{[2
]}

Hasenberg, Lisa M. ^{[1
,2
]}

Li, Yao-En ^{[3
]}

Braatz, Richard D. ^{[1
,2
]}

机构：

[1] MIT, Cambridge, MA 02139 USA

[2] Univ Illinois, Urbana, IL 61801 USA

[3] Abbott Labs, Abbott Pk, IL 60064 USA

来源：

CHEMICAL ENGINEERING SCIENCE | 2012年 / 77卷

关键词：

Concentration feedback control; Crystallizer design; Dual impinging jets; Process intensification; Crystallization; Pharmaceuticals; ATR-FTIR SPECTROSCOPY; CONCENTRATION FEEDBACK-CONTROL; BATCH-COOLING CRYSTALLIZATION; SELECTIVE CRYSTALLIZATION; DESIGN; FORM; TRANSFORMATION; PARACETAMOL; KINETICS; DELIVERY;

D O I：

10.1016/j.ces.2011.12.033

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

A semi-continuous crystallizer configuration that combines continuous seeding using a dual impinging jet with growth rate control in a stirred tank was experimentally demonstrated for the manufacture of L-asparagine monohydrate (LAM) crystals with the objective of obtaining a target flattop size distribution. The dual impinging jets combined hot and cold saturated solutions to generate highly uniform 20-mu m crystals that were further grown to a desired size in the stirred tank with suppressed nucleation that was instrumented with attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy and focused beam reflectance measurement (FBRM). The construction of calibration models and the measurement of solubility and metastable limit were obtained by an automated system that followed preset supersaturation profiles using feedback control. The experiments confirm that greatly enhanced control of the crystal size distribution can be achieved using continuous seeding. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2 / 9

页数：8

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