Application of hairpin DNA-based biosensors with various signal amplification strategies in clinical diagnosis

被引:75
作者
Abolhasan, Rozita [1 ,2 ]
Mehdizadeh, Amir [3 ]
Rashidi, Mohammad Reza [4 ]
Aghebati-Maleki, Leili [5 ,7 ]
Yousefi, Mehdi [6 ,7 ]
机构
[1] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran
[2] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran
[3] Tabriz Univ Med Sci, Endocrine Res Ctr, Tabriz, Iran
[4] Tabriz Univ Med Sci, Res Ctr Pharmaceut Nanotechnol, Tabriz, Iran
[5] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran
[6] Tabriz Univ Med Sci, Aging Res Inst, Tabriz, Iran
[7] Tabriz Univ Med Sci, Dept Immunol, Fac Med Sci, Tabriz, Iran
关键词
DNA biosensors; Diagnosis; Signal amplification; HYBRIDIZATION CHAIN-REACTION; ULTRASENSITIVE ELECTROCHEMICAL DETECTION; ROLLING-CIRCLE AMPLIFICATION; SENSITIVE FLUORESCENCE DETECTION; SEQUENCE-SPECIFIC DETECTION; SURFACE-PLASMON RESONANCE; DUPLEX-SPECIFIC NUCLEASE; MAJORITY LOGIC GATE; TURN-ON DETECTION; STRAND-DISPLACEMENT;
D O I
10.1016/j.bios.2019.01.008
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Biosensors have been commonly used in biomedical diagnostic tools in recent years, because of a wide range of application, such as point-of-care monitoring of treatment and disease progression, drug discovery, commonly use food control, environmental monitoring and biomedical research. Additionally, development of DNA biosensors has been increased enormously over the past few years as confirmed by the large number of scientific publications in this field. A wide range of techniques can be used for the development of DNA biosensors, such as DNA nano-machines and various signal amplification strategies. This article selectively reviews the recent advances in DNA base biosensors with various signal amplification strategies for detection of cancer DNA and microRNA, infectious microorganisms, and toxic metal ions.
引用
收藏
页码:164 / 174
页数:11
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