What are the long-term complications of pediatric ALL treatments and how can they be mitigated? Perspectives on long-term consequences of curative treatment in childhood ALL

被引：1

作者：

Gore, Lia ^{[1
,2
]}

机构：

[1] Univ Colorado, Sch Med, 13123 East 16th Ave,Box B115, Aurora, CO 80045 USA

[2] Univ Colorado, Childrens Hosp Colorado, Ctr Canc & Blood Disorders, Canc Ctr, 13123 East 16th Ave,Box B115, Aurora, CO 80045 USA

来源：

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2022年 / 35卷 / 04期

关键词：

Acute lymphoblastic leukemia; ALL; Cardiovascular disease; Long-term; Osteonecrosis; Pediatric; Toxicities; ACUTE LYMPHOBLASTIC-LEUKEMIA; MINIMAL RESIDUAL DISEASE; PROGNOSTIC-FACTORS; AIEOP-BFM; RISK; CHILDREN; ADOLESCENTS; RELAPSE; OSTEONECROSIS; SURVIVAL;

D O I：

10.1016/j.beha.2022.101403

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Despite cure rates approaching 100% for some subsets of patients, survivors of childhood acute lymphoblastic leukemia (ALL) report a multitude of short-and long-term side effects. Indeed, the long-term complications of pediatric ALL treatment regimens can be associated with significant morbidity and mortality. Identifying mitigation strategies and developing more effective, less toxic therapies is a central goal of current research.

引用

页数：4

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