What are the long-term complications of pediatric ALL treatments and how can they be mitigated? Perspectives on long-term consequences of curative treatment in childhood ALL

被引：1
|
作者：
Gore, Lia [1 ,2 ]
机构：
[1] Univ Colorado, Sch Med, 13123 East 16th Ave,Box B115, Aurora, CO 80045 USA
[2] Univ Colorado, Childrens Hosp Colorado, Ctr Canc & Blood Disorders, Canc Ctr, 13123 East 16th Ave,Box B115, Aurora, CO 80045 USA
来源：
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2022年 / 35卷 / 04期
关键词：
Acute lymphoblastic leukemia; ALL; Cardiovascular disease; Long-term; Osteonecrosis; Pediatric; Toxicities; ACUTE LYMPHOBLASTIC-LEUKEMIA; MINIMAL RESIDUAL DISEASE; PROGNOSTIC-FACTORS; AIEOP-BFM; RISK; CHILDREN; ADOLESCENTS; RELAPSE; OSTEONECROSIS; SURVIVAL;
D O I：
10.1016/j.beha.2022.101403
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Despite cure rates approaching 100% for some subsets of patients, survivors of childhood acute lymphoblastic leukemia (ALL) report a multitude of short-and long-term side effects. Indeed, the long-term complications of pediatric ALL treatment regimens can be associated with significant morbidity and mortality. Identifying mitigation strategies and developing more effective, less toxic therapies is a central goal of current research.
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页数：4
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