Monte Carlo dosimetry for targeted irradiation of individual cells using a microbeam facility

被引：50

作者：

Incerti, S. ^{[1
,2
]}

Seznec, H. ^{[1
,2
]}

Simon, M. ^{[1
,2
]}

Barberet, Ph. ^{[1
,2
]}

Habchi, C. ^{[1
,2
]}

Moretto, Ph. ^{[1
,2
]}

机构：

[1] CEN Bordeaux Gradignan, CNRS, IN2P3, UMR 5797, F-33175 Gradignan, France

[2] Univ Bordeaux, CEN Bordeaux Gradignan, UMR 5797, F-33175 Gradignan, France

来源：

RADIATION PROTECTION DOSIMETRY | 2009年 / 133卷 / 01期

关键词：

CELLULAR IRRADIATION; SIMULATION TOOLKIT; CENBG MICROBEAM; GEANT4; LINE; SOFTWARE; PROTEIN; DESIGN;

D O I：

10.1093/rpd/ncp003

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Microbeam facilities provide a unique opportunity to investigate the effects of ionising radiation on living biological cells with a precise control of the delivered dose. This paper describes dosimetry calculations performed at the single-cell level in the microbeam irradiation facility available at the Centre d'Etudes Nucleaires de Bordeaux-Gradignan in France, using the object-oriented Geant4 Monte Carlo simulation toolkit. The cell geometry model is based on high-resolution three-dimensional voxelised phantoms of a human keratinocyte (HaCaT) cell line. Such phantoms are built from confocal microscopy imaging and from ion beam chemical elemental analysis. Results are presented for single-cell irradiation with 3 MeV incident alpha particles.

引用

页码：2 / 11

页数：10

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