Trait aggression and trait impulsivity are not related to frontal cortex 5-HT2A receptor binding in healthy individuals

被引:29
作者
da Cunha-Bang, Sophie [1 ,2 ]
Stenbaek, Dea Siggaard [1 ,2 ]
Holst, Klaus [1 ,3 ]
Licht, Cecilie Loe [1 ,2 ,4 ,5 ]
Jensen, Peter Steen [1 ,2 ]
Frokjaer, Vibe Gedso [1 ,2 ]
Mortensen, Erik Lykke [4 ,5 ]
Knudsen, Gitte Moos [1 ,2 ]
机构
[1] Copenhagen Univ Hosp, Rigshosp, Neurobiol Res Unit, DK-2100 Copenhagen, Denmark
[2] Copenhagen Univ Hosp, Rigshosp, Ctr Integrated Mol Brain Imaging, DK-2100 Copenhagen, Denmark
[3] Univ Copenhagen, Dept Biostat, Copenhagen, Denmark
[4] Univ Copenhagen, Inst Publ Hlth, Copenhagen, Denmark
[5] Univ Copenhagen, Ctr Hlth Aging, Copenhagen, Denmark
关键词
Aggression; Impulsivity; Serotonin; Positron Emission Tomography (PET); POSITRON-EMISSION-TOMOGRAPHY; BOLUS/INFUSION APPROACH; PERSONALITY-TRAITS; LIFE-COURSE; BEHAVIOR; VIOLENCE; QUESTIONNAIRE; CHILDHOOD; DISORDER; ASSOCIATION;
D O I
10.1016/j.pscychresns.2012.09.007
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Numerous studies indicate that the serotonergic (5-HT) transmitter system is involved in the regulation of impulsive aggression and there is from post-mortem, in vivo imaging and genetic studies evidence that the 5-HT2A receptor may be involved. We investigated 94 healthy individuals (60 men, mean age 47.0 +/- 18.7, range 23-86) to determine if trait aggression and trait impulsivity were related to frontal cortex 5-HT2A receptor binding (5-HT2AR) as measured with [F-18]-altanserin PET imaging. Trait aggression and trait impulsivity were assessed with the Buss-Perry Aggression Questionnaire (AQ) and the Barratt Impulsiveness Scale 11 (BIS-11). Statistical analyses were conducted using a multiple linear regression model and internal consistency reliability of the AQ and BIS-11 was evaluated by Cronbach's alpha. Contrary to our hypothesis, results revealed no significant associations between 5-HT2AR and the AQ or BIS-11 total scores. Also, there was no significant interaction between gender and frontal cortex 5-HT2AR in predicting trait aggression and trait impulsivity. This is the first study to examine how 5-HT2AR relates to trait aggression and trait impulsivity in a large sample of healthy individuals. Our findings are not supportive of a selective role for 5-HT2AR in mediating the 5-HT related effects on aggression and impulsivity in psychiatrically healthy individuals. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:125 / 131
页数:7
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