Immunological modulation of human cardiac mast cells

被引：24

作者：

Marone, G ^{[1
]}

de Crescenzo, G ^{[1
]}

Florio, G ^{[1
]}

Granata, F ^{[1
]}

Dente, V ^{[1
]}

Genovese, A ^{[1
]}

机构：

[1] Univ Naples Federico II, Div Immunol Clin & Allergol, I-80131 Naples, Italy

来源：

NEUROCHEMICAL RESEARCH | 1999年 / 24卷 / 09期

关键词：

anaphylaxis; atherosclerosis; heart; histamine; leukotrienes; mast cells;

D O I：

10.1023/A:1020776807187

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human mast cells, by elaborating Various cytokines, chemokines and proinflammatory mediators play a complex role in several allergic and inflammatory disorders. Mast cells have been identified in human heart tissue in close proximity to the sarcolemma, in perivascular and adventitial locations and in the shoulder region of coronary atheroma. Human heart mast cells (HHMC) can be isolated from patients undergoing heart transplantation and can be immunologically activated in vitro to induce the release of tryptase, chymase, cysteinyl leukotriene C-4 and prostaglandin D-2. Several cytokines (e.g., stem cell factor and TNF-alpha) reside in secretory granules of HHMC. Mast cell density is increased in the hearts of patients with ischemic and idiopathic dilated cardiomyopathy. Cardiac mast cells might contribute to the evolution of atherosclerosis, dilated cardiomyopathy, cardiac and systemic anaphylaxis through the release of cytokines and vasoactive and proinflammatory mediators.

引用

页码：1195 / 1202

页数：8

共 94 条

[31] MAST-CELLS OF 2 TYPES DIFFERING IN NEUTRAL PROTEASE COMPOSITION IN THE HUMAN AORTIC INTIMA - DEMONSTRATION OF TRYPTASE-CONTAINING AND TRYPTASE/CHYMASE-CONTAINING MAST-CELLS IN NORMAL INTIMAS, FATTY STREAKS AND THE SHOULDER REGION OF ATHEROMAS [J].