Effect of kaempferol on the transgenic Drosophila model of Parkinson's disease

被引：26
作者：
Rahul [1 ]
Naz, Falaq [1 ]
Jyoti, Smita [1 ]
Siddique, Yasir Hasan [1 ]
机构：
[1] Aligarh Muslim Univ, Fac Life Sci, Dept Zool, Drosophila Transgen Lab,Sect Genet, Aligarh 202002, Uttar Pradesh, India
来源：
SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期
关键词：
OXIDATIVE STRESS; OLFACTORY DYSFUNCTION; TYROSINE-HYDROXYLASE; SEXUAL DYSFUNCTION; CELL-DEATH; IMPAIRMENT; PROTEIN; MEMORY; BRAIN; GLUTATHIONE;
D O I：
10.1038/s41598-020-70236-2
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The present study was aimed to study the effect of kaempferol, on the transgenic Drosophila model of Parkinson's disease. Kaempferol was added in the diet at final concentration of 10, 20, 30 and 40 mu M and the effect was studied on various cognitive and oxidative stress markers. The results of the study showed that kaempferol, delayed the loss of climbing ability as well as the activity of PD flies in a dose dependent manner compared to unexposed PD flies. A dose-dependent reduction in oxidative stress markers was also observed. Histopathological examination of fly brains using anti-tyrosine hydroxylase immunostaining has revealed a significant dose-dependent increase in the expression of tyrosine hydroxylase in PD flies exposed to kaempferol. Molecular docking results revealed that kaempferol binds to human alpha synuclein at specific sites that might results in the inhibition of alpha synuclein aggregation and prevents the formation of Lewy bodies.
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页数：14
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