Tristaenone A: A New Anti-Inflammatory Compound Isolated from the Australian Indigenous Plant Tristaniopsis laurina

被引：3

作者：

Mathew, Shintu ^{[1
,2
]}

Zhou, Xian ^{[1
]}

Munch, Gerald ^{[1
,2
]}

Bodkin, Francis ^{[2
]}

Wallis, Matthew ^{[3
]}

Li, Feng ^{[3
]}

Raju, Ritesh ^{[2
]}

机构：

[1] Western Sydney Univ, NICM Hlth Res Inst, Penrith, NSW 2751, Australia

[2] Western Sydney Univ, Dept Pharmacol, Campbelltown Campus, Sydney, NSW 2560, Australia

[3] Western Sydney Univ, Sch Sci, Penrith, NSW 2751, Australia

来源：

MOLECULES | 2022年 / 27卷 / 19期

关键词：

Australian indigenous plant; hydroxycyclohexenone; flavonoids; anti-inflammatory; nitric oxide (NO); nuclear factor kappa B (NF-kappa B); INFLAMMATION; DRUGS;

D O I：

10.3390/molecules27196592

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inspired by ethnopharmacological knowledge, we conducted a bioassay-guided fractionation of the leaves of Tristaniopsis laurina which led to the discovery of a new anti-inflammatory compound, tristaenone A (1). The structure was elucidated by detailed spectroscopic data analysis, and the absolute configuration was established using X-ray crystallography analysis. Tristaenone A (1) suppressed LPS and IFN-gamma-induced NO, TNF-alpha and IL-6 production in RAW 264.7 cells with IC50 values of 37.58 +/- 2.45 mu M, 80.6 +/- 5.82 mu M and 125.65 +/- 0.34 mu M, respectively. It also inhibited NF-kappa B nuclear translocation by 52.93 +/- 14.14% at a concentration of 31.85 mu M.

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