Mast cells and eosinophils: A novel link between inflammation and angiogenesis in allergic diseases

被引：120
作者：
Puxeddu, I
Ribatti, D
Crivellato, E
Levi-Schaffer, F
机构：
[1] Hebrew Univ Jerusalem, Fac Med, Sch Pharm, Dept Pharmacol, IL-91120 Jerusalem, Israel
[2] Hebrew Univ Jerusalem, David R Bloom Ctr Pharm, Jerusalem, Israel
[3] Univ Bari, Sch Med, Dept Human Anat & Histol, Bari, Italy
[4] Univ Udine, Sch Med, Dept Med & Morphol Res, Anat Sect, I-33100 Udine, Italy
来源：
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2005年 / 116卷 / 03期
关键词：
mast cells; eosinophils; allergy; angiogenesis; tissue remodeling; asthma; vascular endothelial growth factor;
D O I：
10.1016/j.jaci.2005.06.007
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Mast cells and eosinophils are the key cells in the early and late stages of allergic inflammation. There is increasing evidence that angiogenesis plays an important role both in the development of inflammation and in the pathophysiology of tissue remodeling during allergic disorders. In this review we provide recent data showing a link between allergy and angiogenesis and some possible mechanisms through which vascular endothelial growth factor and the immune system can interact. We discuss the multifaceted roles of mast cells and eosinophils in tissue remodeling and angiogenesis during allergic diseases and whether these cells can be both source and target cells for proangiogenic mediators.
引用
收藏
页码：531 / 536
页数：6
相关论文
共 26 条
[21]   Basic fibroblast growth factor in asthma: Measurement in bronchoalveolar lavage fluid basally and following allergen challenge [J].
Redington, AE ;
Roche, WR ;
Madden, J ;
Frew, AJ ;
Djukanovic, R ;
Holgate, ST ;
Howarth, PH .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 107 (02) :384-387
[22]   Mast cells and their secretory granules are angiogenic in the chick embryo chorioallantoic membrane [J].
Ribatti, D ;
Crivellato, E ;
Candussio, L ;
Nico, B ;
Vacca, A ;
Roncali, L ;
Dammacco, F .
CLINICAL AND EXPERIMENTAL ALLERGY, 2001, 31 (04) :602-608
[23]   The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma [J].
Richter, A ;
Puddicombe, SM ;
Lordan, JL ;
Bucchieri, F ;
Wilson, SJ ;
Djukanovic, R ;
Dent, G ;
Holgate, ST ;
Davies, DE .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2001, 25 (03) :385-391
[24]   Mechanisms of angiogenesis [J].
Risau, W .
NATURE, 1997, 386 (6626) :671-674
[25]   EXUDATIVE HYPERRESPONSIVENESS OF THE AIRWAY MICROCIRCULATION IN SEASONAL ALLERGIC RHINITIS [J].
SVENSSON, C ;
ANDERSSON, M ;
GREIFF, L ;
ALKNER, U ;
PERSSON, CGA .
CLINICAL AND EXPERIMENTAL ALLERGY, 1995, 25 (10) :942-950
[26]   Eosinophil major basic protein: First identified natural heparanase-inhibiting protein [J].
Temkin, V ;
Aingorn, H ;
Puxeddu, I ;
Goldshmidt, O ;
Zcharia, E ;
Gleich, GJ ;
Vlodavsky, I ;
Levi-Schaffer, F .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2004, 113 (04) :703-709
123