Mast cells and eosinophils: A novel link between inflammation and angiogenesis in allergic diseases

被引：121
作者：
Puxeddu, I
Ribatti, D
Crivellato, E
Levi-Schaffer, F
机构：
[1] Hebrew Univ Jerusalem, Fac Med, Sch Pharm, Dept Pharmacol, IL-91120 Jerusalem, Israel
[2] Hebrew Univ Jerusalem, David R Bloom Ctr Pharm, Jerusalem, Israel
[3] Univ Bari, Sch Med, Dept Human Anat & Histol, Bari, Italy
[4] Univ Udine, Sch Med, Dept Med & Morphol Res, Anat Sect, I-33100 Udine, Italy
来源：
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2005年 / 116卷 / 03期
关键词：
mast cells; eosinophils; allergy; angiogenesis; tissue remodeling; asthma; vascular endothelial growth factor;
D O I：
10.1016/j.jaci.2005.06.007
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Mast cells and eosinophils are the key cells in the early and late stages of allergic inflammation. There is increasing evidence that angiogenesis plays an important role both in the development of inflammation and in the pathophysiology of tissue remodeling during allergic disorders. In this review we provide recent data showing a link between allergy and angiogenesis and some possible mechanisms through which vascular endothelial growth factor and the immune system can interact. We discuss the multifaceted roles of mast cells and eosinophils in tissue remodeling and angiogenesis during allergic diseases and whether these cells can be both source and target cells for proangiogenic mediators.
引用
收藏
页码：531 / 536
页数：6
相关论文
共 26 条
[1]   Imbalance between vascular endothelial growth factor and endostatin levels in induced sputum from asthmatic subjects [J].
Asai, K ;
Kanazawa, H ;
Otani, K ;
Shiraishi, S ;
Hirata, K ;
Yoshikawa, J .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2002, 110 (04) :571-575
[2]   THE PATHOLOGY OF ASTHMA, WITH SPECIAL REFERENCE TO CHANGES IN THE BRONCHIAL MUCOSA [J].
DUNNILL, MS .
JOURNAL OF CLINICAL PATHOLOGY, 1960, 13 (01) :27-33
[3]   Expression and function of the vascular endothelial growth factor receptor FLT-1 in human eosinophils [J].
Feistritzer, C ;
Kaneider, NC ;
Sturn, DH ;
Mosheimer, BA ;
Kädhler, CM ;
Wiedermann, CJ .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2004, 30 (05) :729-735
[4]   Endogenous angiogenesis inhibitors [J].
Folkman, J .
APMIS, 2004, 112 (7-8) :496-507
[5]   ANGIOGENESIS IN CANCER, VASCULAR, RHEUMATOID AND OTHER DISEASE [J].
FOLKMAN, J .
NATURE MEDICINE, 1995, 1 (01) :27-31
[6]   Mast cells and vasculature in atopic dermatitis -: potential stimulus of neoangiogenesis [J].
Groneberg, DA ;
Bester, C ;
Grützkau, A ;
Serowka, F ;
Fischer, A ;
Henz, BM ;
Welker, P .
ALLERGY, 2005, 60 (01) :90-97
[7]  
GRUBER BL, 1995, BLOOD, V86, P2488
[8]   Expression of vascular endothelial growth factor by human eosinophils: Upregulation by granulocyte macrophage colony-stimulating factor and interleukin-5 [J].
Horiuchi, T ;
Weller, PF .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1997, 17 (01) :70-77
[9]   Gene expression of vascular endothelial growth factor and its receptors and angiogenesis in bronchial asthma [J].
Hoshino, M ;
Nakamura, Y ;
Hamid, QA .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 107 (06) :1034-1038
[10]   Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis [J].
Hoshino, M ;
Takahashi, M ;
Aoike, N .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 107 (02) :295-301
123