Serum levels of soluble CD26 and CD30 and their clinical significance in patients with rheumatoid arthritis

被引：21

作者：

Ulusoy, Hasan ^{[1
]}

Kamanli, Ayhan ^{[1
]}

Ilhan, Necip ^{[2
]}

Kuru, Omer ^{[3
]}

Arslan, Sule ^{[4
]}

Alkan, Gokhan ^{[1
]}

Ozgocmen, Salih ^{[5
]}

机构：

[1] Firat Univ, Fac Med, Dept Phys Med & Rehabil, Div Rheumatol, TR-23169 Elazig, Turkey

[2] Firat Univ, Dept Biochem, Fac Med, TR-23169 Elazig, Turkey

[3] Ondokuz Mayis Univ, Fac Med, Dept Phys Med & Rehabil, Div Rheumatol, Samsun, Turkey

[4] Gaziosmanpasa Univ, Fac Med, Dept Phys Med & Rehabil, Tokat, Turkey

[5] Erciyes Univ, Gevher Nesibe Hosp, Dept Phys Med & Rehabil, Div Rheumatol,Sch Med, Kayseri, Turkey

来源：

RHEUMATOLOGY INTERNATIONAL | 2012年 / 32卷 / 12期

关键词：

Rheumatoid arthritis; Disease activity; CD26; CD30; DIPEPTIDYL-PEPTIDASE-IV; CD4(+) T-CELLS; SYNOVIAL-FLUID; DISEASE-ACTIVITY; FUNCTIONAL-ROLE; EXPRESSION; INFLAMMATION; CYTOKINES; OSTEOARTHRITIS; PATHOGENESIS;

D O I：

10.1007/s00296-011-2302-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this study was to assess serum levels and clinical significance of soluble CD26 (sCD26) and soluble CD30 (sCD30) in patients with rheumatoid arthritis (RA). Forty-eight patients with RA and 30 healthy controls were enrolled. Serum sCD26 and sCD30 levels were measured using ELISA. Serum sCD26 levels were significantly lower (P = 0.011), whereas sCD30 levels were higher (P = 0.008) in patients with RA than controls. Serum levels of sCD30 correlated significantly with clinical and laboratory parameters of disease activity like erythrocyte sedimentation rate, C-reactive protein, disease activity scores-28 and health assessment questionnaire score; however, sCD26 levels did not correlate any of these activity parameters. These results suggest that serum sCD30 levels increased and correlated significantly with disease activity, indicating a novel follow-up parameter in RA. Serum levels of sCD26 may be lessen but not related to disease activity in RA.

引用

页码：3857 / 3862

页数：6

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