Is the role of the small intestine in first-pass metabolism overemphasized?

被引：0
|
作者：
Lin, JH [1 ]
Chiba, M [1 ]
Baillie, TA [1 ]
机构：
[1] Merck Res Labs, Drug Metab, West Point, PA 19486 USA
来源：
PHARMACOLOGICAL REVIEWS | 1999年 / 51卷 / 02期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：135 / 157
页数：23
相关论文
共 50 条
  • [1] Stereoselective first-pass metabolism of verapamil in the small intestine and liver in rats
    Hanada, Kazuhiko
    Ikemi, Yasutaka
    Kukita, Kazutaka
    Mihara, Kiyoshi
    Ogata, Hiroyasu
    DRUG METABOLISM AND DISPOSITION, 2008, 36 (10) : 2037 - 2042
  • [2] First-pass metabolism of lidocaine in the anesthetized rabbit - Contribution of the small intestine
    Le, KT
    Maurice, H
    duSouich, P
    DRUG METABOLISM AND DISPOSITION, 1996, 24 (07) : 711 - 716
  • [3] First-pass metabolism of midazolam by the human intestine
    Paine, MF
    Shen, DD
    Kunze, KL
    Perkins, JD
    Marsh, CL
    McVicar, JP
    Barr, DM
    Gillies, BS
    Thummel, KE
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 1996, 60 (01) : 14 - 24
  • [4] First-pass metabolism of 5-fluorouracil in the perfused rat small intestine
    Gu, JA
    Yuasa, H
    Hayashi, Y
    Watanabe, J
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 1998, 21 (08) : 871 - 873
  • [5] First-pass effect: Significance of the intestine for absorption and metabolism
    Doherty, MM
    Pang, KS
    DRUG AND CHEMICAL TOXICOLOGY, 1997, 20 (04) : 329 - 344
  • [6] First-pass metabolism of cyclosporine A in human intestine: Inhibition by diltiazem
    Preuner, JG
    Lehle, K
    Eichinger, H
    Rupprecht, L
    TRANSPLANTATION PROCEEDINGS, 1998, 30 (06) : 2545 - 2546
  • [7] First-pass hydrolysis of a propranolol ester derivative in rat small intestine
    Masaki, K
    Taketani, M
    Imai, T
    DRUG METABOLISM AND DISPOSITION, 2006, 34 (03) : 398 - 404
  • [8] Soluble Soybean Polysaccharides Ameliorate L-Carnitine-Induced First-Pass Metabolism in the Small Intestine of Mice
    Li, Wenfeng
    Tao, Wen
    Chen, Luhong
    Zheng, Qiaoran
    Zhou, Feng
    Tan, Si
    Xing, Jie
    Shipin Kexue/Food Science, 2019, 40 (13): : 187 - 194
  • [9] Intestinal First-pass Metabolism of TNP
    Li, Hua
    Deng, Jing-ting
    Zhuang, Xiao-mei
    DRUG METABOLISM REVIEWS, 2010, 42 : 153 - 153
  • [10] FIRST-PASS METABOLISM OF IMIPRAMINE IN MAN
    GRAM, LF
    CHRISTIANSEN, J
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 1975, 17 (05) : 555 - 563
12345