Foundations for engineering biology

被引：911
作者：
Endy, D [1 ]
机构：
[1] MIT, Div Biol Engn, Cambridge, MA 02139 USA
来源：
NATURE | 2005年 / 438卷 / 7067期
关键词：
D O I：
10.1038/nature04342
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Engineered biological systems have been used to manipulate information, construct materials, process chemicals, produce energy, provide food, and help maintain or enhance human health and our environment. Unfortunately, our ability to quickly and reliably engineer biological systems that behave as expected remains quite limited. Foundational technologies that make routine the engineering of biology are needed. Vibrant, open research communities and strategic leadership are necessary to ensure that the development and application of biological technologies remains overwhelmingly constructive.
引用
收藏
页码：449 / 453
页数：5
相关论文
共 41 条
[1]  
[Anonymous], 1999, Eur J Biochem, V264, P610
[2]  
[Anonymous], 1961, COLLECTED WORKS VOL
[3]   Development of genetic circuitry exhibiting toggle switch or oscillatory behavior in Escherichia coli [J].
Atkinson, MR ;
Savageau, MA ;
Myers, JT ;
Ninfa, AJ .
CELL, 2003, 113 (05) :597-607
[4]   Synthetic biology [J].
Benner, SA ;
Sismour, AM .
NATURE REVIEWS GENETICS, 2005, 6 (07) :533-543
[5]   Minimum information about a microarray experiment (MIAME) - toward standards for microarray data [J].
Brazma, A ;
Hingamp, P ;
Quackenbush, J ;
Sherlock, G ;
Spellman, P ;
Stoeckert, C ;
Aach, J ;
Ansorge, W ;
Ball, CA ;
Causton, HC ;
Gaasterland, T ;
Glenisson, P ;
Holstege, FCP ;
Kim, IF ;
Markowitz, V ;
Matese, JC ;
Parkinson, H ;
Robinson, A ;
Sarkans, U ;
Schulze-Kremer, S ;
Stewart, J ;
Taylor, R ;
Vilo, J ;
Vingron, M .
NATURE GENETICS, 2001, 29 (04) :365-371
[6]  
CANTON B, 2005, MIT SYNTHETIC BIOL W
[7]  
Carlson Robert, 2003, Biosecur Bioterror, V1, P203, DOI 10.1089/153871303769201851
[8]   Evolution at two levels: On genes and form [J].
Carroll, SB .
PLOS BIOLOGY, 2005, 3 (07) :1159-1166
[9]   Refactoring bacteriophage T7 [J].
Chan, Leon Y. ;
Kosuri, Sriram ;
Endy, Drew .
MOLECULAR SYSTEMS BIOLOGY, 2005, 1 (1) :2005.0018
[10]   Reverse engineering of biological complexity [J].
Csete, ME ;
Doyle, JC .
SCIENCE, 2002, 295 (5560) :1664-1669
12345