Merkel cell polyomavirus infection occurs during early childhood and is transmitted between siblings

被引：76

作者：

Martel-Jantin, Claire ^{[1
,2
,3
]}

Pedergnana, Vincent ^{[4
,5
]}

Nicol, Jerome T. J. ^{[6
,7
]}

Leblond, Valerie ^{[6
,7
]}

Tregouet, David-Alexandre ^{[8
]}

Tortevoye, Patricia ^{[1
,2
]}

Plancoulaine, Sabine ^{[1
,2
,3
,4
,5
]}

Coursaget, Pierre ^{[6
,7
]}

Touze, Antoine ^{[6
,7
]}

Abel, Laurent ^{[4
,5
,9
]}

Gessain, Antoine ^{[1
,2
]}

机构：

[1] Inst Pasteur, Unite Epidemiol & Physiopathol Virus Oncogenes, Dept Virol, F-75015 Paris, France

[2] CNRS, UMR3569, F-75015 Paris, France

[3] Univ Paris Diderot, Cellule Pasteur, Paris, France

[4] INSERM, Lab Genet Humaine Malad Infect, Branche Necker, U980, F-75015 Paris, France

[5] Univ Paris 05, Sorbonne Paris Cite, Inst Imagine, Paris, France

[6] Univ Tours, Fac Pharm, F-37200 Tours, France

[7] INRA UMR 1282, Unite Infectiol & Sante Publ, F-37200 Tours, France

[8] Univ Paris 06, INSERM UMR S 937, F-75013 Paris 13, France

[9] Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, New York, NY 10021 USA

来源：

JOURNAL OF CLINICAL VIROLOGY | 2013年 / 58卷 / 01期

关键词：

Merkel cell polyomavirus; Transmission mode; Primary infection; Familial study; Correlation; TRANSMISSION; CARCINOMA; INTEGRATION;

D O I：

10.1016/j.jcv.2013.06.004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Merkel cell polyomavirus (MCPyV) is thought to be the etiological agent of Merkel cell carcinoma, but little is known about its distribution and modes of transmission. We conducted seroepidemiological surveys in more than 1000 individuals, from two populations from Cameroon. Overall MCPyV seroprevalence was high in both populations (>75% in adults). Data from the first population, comprising mainly children, indicated that MCPyV infections mostly occurred during early childhood, after the disappearance of specific maternal antibodies. Results from the second family-based population provided evidence for familial aggregation of MCPyV infection status. We observed significant sib-sib correlation (odds ratio = 3.42 [95% CI 1.27-9.19], p = 0.014), particularly for siblings close together in age, and a trend for mother-child correlation (OR = 2.71 [0.86-8.44], p = 0.08). Overall, our results suggest that MCPyV infection is acquired through close contact, possibly involving saliva and/or the skin, especially between young siblings and between mothers and their children. (c) 2013 The Authors. Published by Elsevier B.V. All rights reserved.

引用

页码：288 / 291

页数：4

共 19 条

[11] Human herpesvirus 8 transmission from mother to child and between siblings in an endemic population [J].