Micellar electrokinetic capillary chromatography as an alternative method for the determination of ethinylestradiol and levo-norgestrel

被引:21
作者
Berzas, JJ [1 ]
Del Castillo, B
Castañeda, G
Pinilla, MJ
机构
[1] Univ Castilla La Mancha, Dept Quim Analit & Tecnol Alimentos, Fac Quim, E-13071 Ciudad Real, Spain
[2] Univ Complutense Madrid, Fac Farm, Secc Dept Quim Analit, Madrid, Spain
关键词
ethinylestradiol; levo-norgestrel; micellar electrokinetic chromatography (MEKC); oral contraceptives;
D O I
10.1016/S0039-9140(99)00030-2
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A method for quantifying of ethinylestradiol (ETE) and levo-norgestrel (LEV) in pharmaceutical products by micellar electrokinetic chromatography (MEKC) is described. The separation was carried out at 25 degrees C and 25 kV, using a 20 mM berate buffer (pH 9.2), 15 mM sodium dodecylsulfate (SDS) in 30% acetonitrile/water (v/v). Under these conditions the analysis takes about 7 min. The method has been applied for quantifying both compounds in six different commercial contraceptives and the proposed method gave good results when compared with a reference liquid chromatographic (LC) method. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:261 / 268
页数:8
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