Antidiabetic Properties of Naringenin: A Citrus Fruit Polyphenol

被引：171
作者：
Den Hartogh, Danja J. [1 ,2 ]
Tsiani, Evangelia [1 ,2 ]
机构：
[1] Brock Univ, Dept Hlth Sci, St Catharines, ON L2S 3A1, Canada
[2] Brock Univ, Ctr Bone & Muscle Hlth, St Catharines, ON L2S 3A1, Canada
来源：
BIOMOLECULES | 2019年 / 9卷 / 03期
基金：
加拿大自然科学与工程研究理事会;
关键词：
insulin resistance; diabetes; naringenin; naringin; skeletal muscle; adipose; liver; pancreas; INSULIN-RESISTANCE; OXIDATIVE STRESS; IN-VIVO; FLAVONOID NARINGENIN; METABOLIC SYNDROME; HEPATIC STEATOSIS; LIPID-METABOLISM; ADIPOSE-TISSUE; GLUCOSE-UPTAKE; B SECRETION;
D O I：
10.3390/biom9030099
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by insulin resistance and hyperglycemia and is associated with personal health and global economic burdens. Current strategies/approaches of insulin resistance and T2DM prevention and treatment are lacking in efficacy resulting in the need for new preventative and targeted therapies. In recent years, epidemiological studies have suggested that diets rich in vegetables and fruits are associated with health benefits including protection against insulin resistance and T2DM. Naringenin, a citrus flavanone, has been reported to have antioxidant, anti-inflammatory, hepatoprotective, nephroprotective, immunomodulatory and antidiabetic properties. The current review summarizes the existing in vitro and in vivo animal studies examining the anti-diabetic effects of naringenin.
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页数：21
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