'Normal' P300 amplitude predicts rapid response to ECT in melancholia

被引：28

作者：

Ancy, J ^{[1
]}

Gangadhar, BN ^{[1
]}

Janakiramaiah, N ^{[1
]}

机构：

[1] NATL INST MENTAL HLTH & NEUROSCI,DEPT PSYCHIAT,BANGALORE 560029,KARNATAKA,INDIA

来源：

JOURNAL OF AFFECTIVE DISORDERS | 1996年 / 41卷 / 03期

关键词：

electro-convulsive therapy; time-course of response; P300 event related potential; melancholia; prediction of ECT response;

D O I：

10.1016/S0165-0327(96)00090-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Consenting melancholic depressives (n = 17) were treated with bilateral ECT under anaesthesia. All patients except two were antidepressant-naive. The auditory P300 event-related potential (ERP) was recorded before and after the ECT course. The latency of P300 in depressives before treatment did not differ from controls, but the amplitude was smaller than in matched controls (n=15). The P300 amplitude was larger in depressives who had rapid response than in the rest. Rapid responders did not differ from controls on P300 amplitude before treatment. Hence it is suggested that 'Normal' P300 predicts rapid therapeutic response to ECT in melancholia.

引用

页码：211 / 215

页数：5

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