Polyoxygenated diterpenoids of the eunicellin-type from the Chinese soft coral Cladiella krempfi

被引：21

作者：

Cai, You-Sheng ^{[1
]}

Yao, Li-Gong ^{[1
]}

Di Pascale, Antonio ^{[2
]}

Irace, Carlo ^{[2
]}

Mollo, Ernesto ^{[3
]}

Taglialatela-Scafati, Orazio ^{[4
]}

Guo, Yue-Wei ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China

[2] Univ Naples Federico II, Dipartimento Farmacol Sperimentale, I-80131 Naples, Italy

[3] Ist Chim Biomol ICB CNR, I-80078 Naples, Italy

[4] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

来源：

TETRAHEDRON | 2013年 / 69卷 / 09期

基金：

欧盟第七框架计划;

关键词：

Cladiella krempfi; Diterpenoids; Eunicellin; Structure elucidation; Bioactivity; SINULARIA-FLEXIBILIS; LITOPHYTON SP; A-D; SCLEROPHYTIN; OCTOCORALLIA;

D O I：

10.1016/j.tet.2012.12.051

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A detailed chemical investigation of the Chinese soft coral Cladiella krempfi has yielded four new eunicellin-based diterpenoids along with five known compounds. The stereostructures of the new metabolites have been elucidated by extensive spectroscopic analysis, mainly based on 2D NMR spectroscopy, and by chemical transformations. A remarkable variation in the diterpene composition in dependence of the exact site of collection was observed. Some of the isolated diterpenoids were shown to exhibit antiproliferative activity against C6 glioma cells, multi-drug resistant tumor cell line. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2214 / 2219

页数：6

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