Flucloxacillin-induced liver injury

被引：23

作者：

Andrews, Elise ^{[1
]}

Daly, Ann K. ^{[1
]}

机构：

[1] Univ Newcastle, Sch Med, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

TOXICOLOGY | 2008年 / 254卷 / 03期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Flucloxacillin; Drug-induced liver injury; Cytochrome P450;

D O I：

10.1016/j.tox.2008.08.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Flucloxacillin is a common cause of drug-induced liver injury in Europe, affecting in the region of 8.5 in every 100,000 first time users of the drug. The mechanism by which the drug causes the liver injury is currently unknown but it is believed to be influenced by a combination of genetic and environmental factors. This review summarises what is currently known about the disposition of flucloxacillin in the liver, considers potential mechanisms by which flucloxacillin may cause the liver injury, and suggests candidate genes which could determine individual susceptibility to flucloxacillin-induced liver injury. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：158 / 163

页数：6

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