Effect of immobilization of poly(γ-glutamic acid) on the biocompatibility of electrospun poly (L-lactide) mats

被引：5
作者：
Chen, Chien-Hsin [1 ]
Yang, Ming-Chien [1 ]
Yu, Da-Guang [2 ]
Jou, Chi-Hsiung [2 ]
机构：
[1] Natl Taiwan Univ Sci & Technol, Dept Mat Sci & Engn, Taipei 10607, Taiwan
[2] Oriental Inst Technol, Dept Mat & Text, New Taipei 22061, Taiwan
来源：
JOURNAL OF POLYMER RESEARCH | 2018年 / 25卷 / 04期
关键词：
Electrospinning; Poly (L-lactic acid); Poly (gamma-glutamic acid); Plasma treatment; Cytocompatibility; BIODEGRADABLE POLYMERS; ELECTRIC-FIELD; POLY(L-LACTIDE); MEMBRANES; FIBERS; POLYLACTIDES; DEGRADATION; DEVICES;
D O I：
10.1007/s10965-018-1488-4
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
In this study, poly(L-lactide) ( PLLA) non-woven mats were prepared by electrospinning technique, followed by treating with oxygen plasma and grafting with 3-aminopropyl triethoxysilane (APTES), then immersed in poly(gamma-glutamic acid) (gamma-PGA) solution to form a layer of gamma-PGA on the surface. In so doing, hydrophobic PLLA would become highly hydrophilic. Through characterization of hydrophilicity and biocompatibility, the feasibility of these modified mats for wound dressing was evaluated. The results show that after the grafting of gamma-PGA, the swelling ratio increased greatly from 7% for pristine PLLA mat to 321% for gamma-PGA-grafted PLLA mat, and the contact angle decreased from 112 degrees to 25 degrees. In vitro cytocompatibility tests against L929 fibroblast show that gamma-PGA-grafted PLLA was non-cytotoxic. In addition, the proliferation of fibroblasts was higher on gamma-PGA-grafted PLLA than on pristine PLLA.
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页数：7
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