Genetic and pathogenic characterization of SARS-CoV-2: a review

被引：15

作者：

Bahrami, Afsane ^{[1
]}

Ferns, Gordon A. ^{[2
]}

机构：

[1] Birjand Univ Med Sci, Cellular & Mol Res Ctr, Birjand, Iran

[2] Brighton & Sussex Med Sch, Div Med Educ, Brighton BN1 9PH, Sussex, England

来源：

FUTURE VIROLOGY | 2020年 / 15卷 / 08期

关键词：

betacoronavirus; remidisvir; SARS-CoV-2; spike surface glycoprotein; RESPIRATORY SYNDROME CORONAVIRUS; BRONCHITIS-VIRUS-E; SPIKE PROTEIN; CLINICAL CHARACTERISTICS; NLRP3; INFLAMMASOME; DISEASE; 2019; CELL ENTRY; SARS; WUHAN; PNEUMONIA;

D O I：

10.2217/fvl-2020-0129

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The first case of Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported in December 2019. This virus belongs to the beta-coronavirus group that contains a single stranded RNA with a nucleoprotein within a capsid. SARS-CoV-2 shares 80% nucleotide identity to SARS-CoV. The virus is disseminated by its binding to the ACE2 receptors on bronchial epithelial cells. The diagnosis of COVID-19 is based on a laboratory-based reverse transcription polymerase chain reaction (RT-PCR) test together with chest computed tomography imaging. To date, no antiviral therapy has been approved, and many aspects of the COVID-19 are unknown. In this review, we will focus on the recent information on genetics and pathogenesis of COVID-19 as well as its clinical presentation and potential treatments.

引用

页码：533 / 549

页数：17

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