Nanoparticle-membrane interactions

被引：127
|
作者：
Contini, Claudia [1 ]
Schneemilch, Matthew [1 ]
Gaisford, Simon [2 ]
Quirke, Nick [1 ]
机构：
[1] Imperial Coll London, Dept Chem, London, England
[2] UCL, UCL Sch Pharm, Dept Pharmaceut, London, England
来源：
JOURNAL OF EXPERIMENTAL NANOSCIENCE | 2018年 / 13卷 / 01期
基金：
欧盟地平线“2020”;
关键词：
nanotoxicity; nanomaterial; membrane interface; nanoparticle; ISOTHERMAL TITRATION CALORIMETRY; CELLULAR UPTAKE; SILICA NANOPARTICLES; GOLD NANOPARTICLES; LIPID-BILAYERS; PARTICLE-SIZE; ENGINEERED NANOPARTICLES; VESICLES; CYTOTOXICITY; ENDOCYTOSIS;
D O I：
10.1080/17458080.2017.1413253
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Engineered nanomaterials have a wide range of applications and as a result, are increasingly present in the environment. While they offer new technological opportunities, there is also the potential for adverse impact, in particular through possible toxicity. In this review, we discuss the current state of the art in the experimental characterisation of nanoparticle-membrane interactions relevant to the prediction of toxicity arising from disruption of biological systems. One key point of discussion is the urgent need for more quantitative studies of nano-bio interactions in experimental models of lipid system that mimic in vivo membranes.
引用
收藏
页码：62 / 81
页数：20
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