In the past two decades, a substantial increase in the incidence of acute kidney injury (AKI) and kidney injury requiring dialysis has occurred in North America. This increase has coincided with an increase in the incidence of end-stage renal disease (ESRD), which has exceeded that expected based upon the prevalence of chronic kidney disease (CKD). In order to better understand the association between these conditions, there has been a proliferation of studies that have examined the risks of incident and progressive CKD following AKI. Animal studies have shown that failed differentiation of epithelial cells following renal ischaemia-reperfusion injury might lead to tubulointerstitial fibrosis, supporting a biological mechanism linking AKI and CKD. Strong and consistent associations between AKI and incident CKD, progression of CKD and incident ESRD have also been shown in epidemiological studies. In this Review, we summarize the wealth of available data on the relationship between AKI and CKD, and discuss the implications of these findings for the long-term clinical management of patients following AKI. We also identify areas of active investigation and future directions for research. Leung, K. C. W. et al. Nat. Rev. Nephrol. 9, 77-85 (2013); published online 18 December 2012; doi:10.1038/nrneph.2012.280
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Adiyanti Sri S, 2012, Acta Med Indones, V44, P246
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Vet Affairs Med Ctr, Res & Med Serv, Washington, DC 20422 USA
Georgetown Univ, Sch Med, Dept Psychiat, Washington, DC USAGeorge Washington Univ, Med Ctr, Dept Med, Div Renal Dis & Hypertens, Washington, DC 20037 USA
Amdur, Richard L.
Chawla, Lakhmir S.
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George Washington Univ, Med Ctr, Dept Med, Div Renal Dis & Hypertens, Washington, DC 20037 USA
George Washington Univ, Med Ctr, Dept Anesthesiol & Crit Care Med, Washington, DC 20037 USAGeorge Washington Univ, Med Ctr, Dept Med, Div Renal Dis & Hypertens, Washington, DC 20037 USA
Chawla, Lakhmir S.
Amodeo, Susan
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Vet Affairs Med Ctr, Res & Med Serv, Washington, DC 20422 USA
Vet Affairs Med Ctr, Fiscal Serv, Washington, DC 20422 USAGeorge Washington Univ, Med Ctr, Dept Med, Div Renal Dis & Hypertens, Washington, DC 20037 USA
Amodeo, Susan
Kimmel, Paul L.
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George Washington Univ, Med Ctr, Dept Med, Div Renal Dis & Hypertens, Washington, DC 20037 USA
NIDDK, Div Kidney Urol & Hematol Dis, NIH, Bethesda, MD USAGeorge Washington Univ, Med Ctr, Dept Med, Div Renal Dis & Hypertens, Washington, DC 20037 USA
Kimmel, Paul L.
Palant, Carlos E.
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George Washington Univ, Med Ctr, Dept Med, Div Renal Dis & Hypertens, Washington, DC 20037 USA
Vet Affairs Med Ctr, Res & Med Serv, Washington, DC 20422 USAGeorge Washington Univ, Med Ctr, Dept Med, Div Renal Dis & Hypertens, Washington, DC 20037 USA
机构:
Vet Affairs Med Ctr, Res & Med Serv, Washington, DC 20422 USA
Georgetown Univ, Sch Med, Dept Psychiat, Washington, DC USAGeorge Washington Univ, Med Ctr, Dept Med, Div Renal Dis & Hypertens, Washington, DC 20037 USA
Amdur, Richard L.
Chawla, Lakhmir S.
论文数: 0引用数: 0
h-index: 0
机构:
George Washington Univ, Med Ctr, Dept Med, Div Renal Dis & Hypertens, Washington, DC 20037 USA
George Washington Univ, Med Ctr, Dept Anesthesiol & Crit Care Med, Washington, DC 20037 USAGeorge Washington Univ, Med Ctr, Dept Med, Div Renal Dis & Hypertens, Washington, DC 20037 USA
Chawla, Lakhmir S.
Amodeo, Susan
论文数: 0引用数: 0
h-index: 0
机构:
Vet Affairs Med Ctr, Res & Med Serv, Washington, DC 20422 USA
Vet Affairs Med Ctr, Fiscal Serv, Washington, DC 20422 USAGeorge Washington Univ, Med Ctr, Dept Med, Div Renal Dis & Hypertens, Washington, DC 20037 USA
Amodeo, Susan
Kimmel, Paul L.
论文数: 0引用数: 0
h-index: 0
机构:
George Washington Univ, Med Ctr, Dept Med, Div Renal Dis & Hypertens, Washington, DC 20037 USA
NIDDK, Div Kidney Urol & Hematol Dis, NIH, Bethesda, MD USAGeorge Washington Univ, Med Ctr, Dept Med, Div Renal Dis & Hypertens, Washington, DC 20037 USA
Kimmel, Paul L.
Palant, Carlos E.
论文数: 0引用数: 0
h-index: 0
机构:
George Washington Univ, Med Ctr, Dept Med, Div Renal Dis & Hypertens, Washington, DC 20037 USA
Vet Affairs Med Ctr, Res & Med Serv, Washington, DC 20422 USAGeorge Washington Univ, Med Ctr, Dept Med, Div Renal Dis & Hypertens, Washington, DC 20037 USA