Population-based coverage survey results following the mass drug administration of azithromycin for the treatment of trachoma in Amhara, Ethiopia

被引:27
作者
Astale, Tigist [1 ]
Sata, Eshetu [1 ]
Zerihun, Mulat [1 ]
Nute, Andrew W. [2 ]
Stewart, Aisha E. P. [2 ]
Gessese, Demelash [1 ]
Ayenew, Gedefaw [1 ]
Melak, Berhanu [1 ]
Chanyalew, Melsew [3 ]
Tadesse, Zerihun [1 ]
Callahan, E. Kelly [2 ]
Nash, Scott D. [2 ]
机构
[1] Carter Ctr, Trachoma Control Program, Addis Ababa, Ethiopia
[2] Carter Ctr, Trachoma Control Program, Atlanta, GA USA
[3] Amhara Reg Hlth Bur, Hlth Promot & Dis Prevent Core Proc, Bahir Dar, Ethiopia
关键词
ELIMINATE LYMPHATIC FILARIASIS; PROGRAM; ORISSA;
D O I
10.1371/journal.pntd.0006270
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background Trachoma is the leading infectious cause of blindness worldwide. In communities where the district level prevalence of trachomatous inflammation-follicular among children ages 1-9 years is >= 5%, WHO recommends annual mass drug administration (MDA) of antibiotics with the aim of at least 80% coverage. Population-based post-MDA coverage surveys are essential to understand the effectiveness of MDA programs, yet published reports from trachoma programs are rare. Methods In the Amhara region of Ethiopia, a population-based MDA coverage survey was conducted 3 weeks following the 2016 MDA to estimate the zonal prevalence of self-reported drug coverage in all 10 administrative zones. Survey households were selected using a multi-stage cluster random sampling design and all individuals in selected households were presented with a drug sample and asked about taking the drug during the campaign. Zonal estimates were weighted and confidence intervals were calculated using survey procedures. Self reported drug coverage was then compared with regional reported administrative coverage. Results Region-wide, 24,248 individuals were enumerated, of which, 20,942 (86.4%) individuals were present. The regional self-reported antibiotic coverage was 76.8% (95%Confidence Interval (CI):69.3-82.9%) in the population overall and 77.4% (95%Cl = 65.7-85.9%) among children ages 1-9 years old. Zonal coverage ranged from 67.8% to 90.2%. Five out of 10 zones achieved a coverage >80%. In all zones, the reported administrative coverage was greater than 90% and was considerably higher than self-reported MDA coverage. Main reasons reported for MDA campaign non-attendance included being physically unable to get to MDA site (22.5%), traveling (20.6%), and not knowing about the campaign (21.0%). MDA refusal was low (2.8%) in this population. Conclusions Although self-reported MDA coverage in Amhara was greater than 80% in some zones, programmatic improvements are warranted throughout Amhara to achieve higher coverage. These results will be used to enhance community mobilization and improve training for MDA distributors and supervisors to improve coverage in future MDAs.
引用
收藏
页数:13
相关论文
共 28 条
[21]   Enhanced antibiotic distribution strategies and the potential impact of facial cleanliness and environmental improvements for the sustained control of trachoma: a modelling study [J].
Pinsent, Amy ;
Burton, Matthew J. ;
Gambhir, Manoj .
BMC MEDICINE, 2016, 14
[22]   Travel and Implications for the Elimination of Trachoma in Ethiopia [J].
Shah, Neelima A. ;
House, Jenafir ;
Lakew, Takele ;
Alemayehu, Wondu ;
Halfpenny, Colleen ;
Hong, Kevin C. ;
Keenan, Jeremy D. ;
Porco, Travis C. ;
Whitcher, John P. ;
Lietman, Thomas M. ;
Gaynor, Bruce D. .
OPHTHALMIC EPIDEMIOLOGY, 2010, 17 (02) :113-117
[23]   Mass Treatment with Azithromycin for Trachoma Control: Participation Clusters in Households [J].
Ssemanda, Elizabeth N. ;
Munoz, Beatriz ;
Harding-Esch, Emma M. ;
Edwards, Tansy ;
Mkocha, Harran ;
Bailey, Robin L. ;
Sillah, Ansumana ;
Stare, Dianne ;
Mabey, David C. W. ;
West, Sheila K. .
PLOS NEGLECTED TROPICAL DISEASES, 2010, 4 (10)
[24]   A Randomized Trial of Two Coverage Targets for Mass Treatment with Azithromycin for Trachoma [J].
West, Sheila K. ;
Bailey, Robin ;
Munoz, Beatriz ;
Edwards, Tansy ;
Mkocha, Harran ;
Gaydos, Charlotte ;
Lietman, Thomas ;
Porco, Travis ;
Mabey, David ;
Quinn, Thomas C. .
PLOS NEGLECTED TROPICAL DISEASES, 2013, 7 (08)
[25]  
WHO, 2010, 3 GLOB SCI M TRACH
[26]  
World Health Organization, 2013, DAT QUAL ASS NEGL TR
[27]  
World Health Organization (WHO), 2017, WKLY EPIDEMIOL REC, V92, P357
[28]   Drug Coverage Surveys for Neglected Tropical Diseases: 10 Years of Field Experience [J].
Worrell, Caitlin ;
Mathieu, Els .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2012, 87 (02) :216-222