Phenotypic and genotypic characterisaton of drug-resistant Plasmodium vivax

被引：61
作者：
Price, Ric N. [1 ,2 ]
Auburn, Sarah [1 ]
Marfurt, Jutta [1 ]
Cheng, Qin [3 ,4 ]
机构：
[1] Charles Darwin Univ, Menzies Sch Hlth Res, Global & Trop Hlth Div, Darwin, NT 0909, Australia
[2] Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Oxford OX1 2JD, England
[3] Australian Army Malaria Inst, Dept Drug Resistance & Diagnost, Brisbane, Qld, Australia
[4] Queensland Inst Med Res, Brisbane, Qld 4006, Australia
来源：
TRENDS IN PARASITOLOGY | 2012年 / 28卷 / 11期
基金：
英国惠康基金; 瑞士国家科学基金会;
关键词：
Plasmodium vivax; drug resistance; malaria; clinical trials; chloroquine; in vitro drug susceptibility test; genotyping; molecular markers; HUMAN MALARIA PARASITE; IN-VITRO EFFICACY; REDUCTASE-THYMIDYLATE SYNTHASE; AMINO-ACID MUTATIONS; REPUBLIC-OF-KOREA; PAPUA-NEW-GUINEA; SULFADOXINE-PYRIMETHAMINE; CHLOROQUINE RESISTANCE; PVCRT-O; POSITIVE SELECTION;
D O I：
10.1016/j.pt.2012.08.005
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
In this review we present recent developments in the analysis of Plasmodium vivax clinical trials and ex vivo drug-susceptibility assays, as well approaches currently being used to identify molecular markers of drug resistance. Clinical trials incorporating the measurement of in vivo drug concentrations and parasite clearance times are needed to detect early signs of resistance. Analysis of P. vivax growth dynamics ex vivo have defined the criteria for acceptable assay thresholds for drug susceptibility testing, and their subsequent interpretation. Genotyping and next-generation sequencing studies in P. vivax field isolates are set to transform our understanding of the molecular mechanisms of drug resistance.
引用
收藏
页码：522 / 529
页数：8
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