Viruses and bacteria in Th2-biased allergic airway disease

被引：44

作者：

Lan, F. ^{[1
,2
]}

Zhang, N. ^{[1
]}

Gevaert, E. ^{[1
]}

Zhang, L. ^{[2
]}

Bachert, C. ^{[1
,3
]}

机构：

[1] Univ Ghent, ENT Dept, Upper Airways Res Lab, Ghent, Belgium

[2] Capital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China

[3] Karolinska Inst, Div ENT Dis, Clintec, Stockholm, Sweden

来源：

ALLERGY | 2016年 / 71卷 / 10期

关键词：

allergy rhinitis; asthma; chronic rhinosinusitis; microbiome; Th2; response; STAPHYLOCOCCUS-AUREUS COLONIZATION; THYMIC STROMAL LYMPHOPOIETIN; RESPIRATORY VIRUSES; CHRONIC RHINOSINUSITIS; IMMUNE-RESPONSES; EPITHELIAL-CELLS; TH2; CYTOKINES; 1ST YEAR; MUCOCILIARY DIFFERENTIATION; ASTHMA EXACERBATIONS;

D O I：

10.1111/all.12934

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Allergic airway diseases are typically characterized by a type 2-biased inflammation. Multiple distinct viruses and bacteria have been detected in the airways. Recently, it has been confirmed that the microbiome of allergic individuals differs from that of healthy subjects, showing a close relationship with the type 2 response in allergic airway disease. In this review, we summarize the recent findings on the prevalence of viruses and bacteria in type 2-biased airway diseases and on the mechanisms employed by viruses and bacteria in propagating type 2 responses. The understanding of the microbial composition and postinfectious immune programming is critical for the reconstruction of the normal microflora and immune status in allergic airway diseases.

引用

页码：1381 / 1392

页数：12

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