Risk Factors Associated With Contrast-Induced Nephropathy after Primary Percutaneous Coronary Intervention

被引:3
作者
Kumar, Dileep [1 ]
Liaquat, Hussain [1 ]
Sial, Jawaid A. [1 ]
Saghir, Tahir [1 ]
Kumari, Rekha [2 ]
Kumar, Hitesh [2 ]
Karim, Musa [3 ]
Rai, Kelash [4 ]
Bai, Reeta [5 ]
机构
[1] Natl Inst Cardiovasc Dis, Cardiol, Karachi, Pakistan
[2] Govt Sindh, Mithi, Pakistan
[3] Natl Inst Cardiovasc Dis, Res, Karachi, Pakistan
[4] Wayne State Univ, Internal Med, Detroit, MI USA
[5] Dow Univ Hlth Sci, Radiol, Karachi, Pakistan
关键词
contrast-induced nephropathy; st-segment elevation myocardial infarction; primary percutaneous coronary intervention; acute kidney injury; ST-SEGMENT ELEVATION; CHRONIC KIDNEY-DISEASE; HYDRATION; OUTCOMES; SCORE; MULTICENTER; INJURY; SIN;
D O I
10.7759/cureus.9721
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Contrast-induced nephropathy (CIN) after primary percutaneous coronary intervention (PCI) is associated with increased mortality and morbidity. The aim of this study is to determine the frequency of CIN after primary PCI and its association with risk factors in patients with ST-segment elevation myocardial infarction (STEMI) at a tertiary care cardiac center in Pakistan. Methodology In this observational study, we included 282 patients who presented with STEMI and underwent primary PCI at the National Institute of Cardiovascular Disease, Karachi, Pakistan, from October 2017 to April 2018. The serum creatinine (mg/dL) levels were obtained at baseline and 48 to 72 hours after the primary PCI procedure, and patients with a 25% increase or >= 0.5 mg/dL rise in post-procedure creatinine level (after 48 to 72 hour) were categorized for CIN. Results Out of a total sample of 282 patients, 68.4% (193) were males, and the mean age was 56.4 +/- 9.1 years. A majority of the patients, 78.7% (222), were hypertensive and 34% (96) were diabetic. The CIN was observed in 13.1% (37) of the patients, and increased risk of CIN was found to be associated with the presence of diabetes mellitus and increased (>200 mL) use of contrast during the procedure, with odds ratios of 2.3 (1.14-4.63) and 3.12 (1.36-7.17), respectively. Conclusions The CIN after PCI is a common complication associated with the presence of diabetes mellitus and the use of an increased amount of contrast during the procedure.
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页数:8
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