Mesenchymal Stem Cells and Induced Pluripotent Stem Cells as Therapies for Multiple Sclerosis

被引：42

作者：

Xiao, Juan ^{[1
,2
,3
]}

Yang, Rongbing ^{[2
]}

Biswas, Sangita ^{[3
]}

Qin, Xin ^{[1
]}

Zhang, Min ^{[1
]}

Deng, Wenbin ^{[1
,3
]}

机构：

[1] Hubei Univ Arts & Sci, Coll Med, Xiangyang 441053, Peoples R China

[2] Handan Cent Hosp, Dept Biol Treatment, Handan 056001, Peoples R China

[3] Univ Calif Davis, Sch Med, Dept Biochem & Mol Med, Davis, CA 95817 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2015年 / 16卷 / 05期

基金：

美国国家卫生研究院;

关键词：

mesenchymal stem cells; induced pluripotent stem cells; neural stem cell; multiple sclerosis; LEUKEMIA INHIBITORY FACTOR; MONOCYTE CHEMOATTRACTANT PROTEIN-1; OLIGODENDROCYTE PROGENITOR CELLS; IN-VITRO; PRECURSOR CELLS; STROMAL CELLS; IFN-GAMMA; DIFFERENTIATION; CNS; DISORDERS;

D O I：

10.3390/ijms16059283

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory demyelinating disorder of the central nervous system that leads to permanent neurological deficits. Current MS treatment regimens are insufficient to treat the irreversible neurological disabilities. Tremendous progress in the experimental and clinical applications of cell-based therapies has recognized stem cells as potential candidates for regenerative therapy for many neurodegenerative disorders including MS. Mesenchymal stem cells (MSC) and induced pluripotent stem cell (iPSCs) derived precursor cells can modulate the autoimmune response in the central nervous system (CNS) and promote endogenous remyelination and repair process in animal models. This review highlights studies involving the immunomodulatory and regenerative effects of mesenchymal stem cells and iPSCs derived cells in animal models, and their translation into immunomodulatory and neuroregenerative treatment strategies for MS.

引用

页码：9283 / 9302

页数：20

共 86 条

[1] Human mesenchymal stem cells modulate allogeneic immune cell responses [J].

Aggarwal, S ;

Pittenger, MF .

BLOOD, 2005, 105 (04) :1815-1822

[2] Primary progressive multiple sclerosis: part of the MS disease spectrum or separate disease entity? [J].

Antel, Jack ;

Antel, Samson ;

Caramanos, Zografos ;

Arnold, Douglas L. ;

Kuhlmann, Tanja .

ACTA NEUROPATHOLOGICA, 2012, 123 (05) :627-638

[3]

Ardeshiry Lajimi A., 2014, INT J HEMATOL ONCOL, V7, P15

[4] Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy [J].

Baglio, Serena Rubina ;

Pegtel, D. Michiel ;

Baldini, Nicola .

FRONTIERS IN PHYSIOLOGY, 2012, 3

[5] Hepatocyte growth factor mediates mesenchymal stem cell-induced recovery in multiple sclerosis models [J].

Bai, Lianhua ;

Lennon, Donald P. ;

Caplan, Arnold I. ;

DeChant, Anne ;

Hecker, Jordan ;

Kranso, Janet ;

Zaremba, Anita ;

Miller, Robert H. .

NATURE NEUROSCIENCE, 2012, 15 (06) :862-U86

[6] Epigenetic Memory and Preferential Lineage-Specific Differentiation in Induced Pluripotent Stem Cells Derived from Human Pancreatic Islet Beta Cells [J].

Bar-Nur, Ori ;

Russ, Holger A. ;

Efrat, Shimon ;

Benvenisty, Nissim .

CELL STEM CELL, 2011, 9 (01) :17-23

[7] Prospects of Cell Therapy for Disorders of Myelin [J].

Ben-Hur, Tamir ;

Goldman, Steven A. .

YEAR IN NEUROLOGY 2008, 2008, 1142 :218-249

[8] Cell-Based Reparative Therapies for Multiple Sclerosis [J].

Ben-Hur, Tamir ;

Fainstein, Nina ;

Nishri, Yossi .

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, 2013, 13 (11)

[9] Hepatocyte growth factor inhibits CNS autoimmunity by inducing tolerogenic dendritic cells and CD25+Foxp3+ regulatory T cells [J].

Benkhoucha, Mahdia ;

Santiago-Raber, Marie-Laure ;

Schneiter, Gregory ;

Chofflon, Michel ;

Funakoshi, Hiroshi ;

Nakamura, Toshikazu ;

Lalive, Patrice H. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (14) :6424-6429

[10] Blood-brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE [J].

Bennett, Jami ;

Basivireddy, Jayasree ;

Kollar, Anita ;

Biron, Kaan E. ;

Reickmann, Peter ;

Jefferies, Wilfred A. ;

McQuaid, Stephen .

JOURNAL OF NEUROIMMUNOLOGY, 2010, 229 (1-2) :180-191

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