Synthesis, Characterization, and Antimicrobial Activity of Nano-Hydroxyapatite-Zinc for Bone Tissue Engineering Applications

被引：52

作者：

Swetha, M. ^{[1
]}

Sahithi, K. ^{[1
]}

Moorthi, A. ^{[1
]}

Saranya, N. ^{[1
]}

Saravanan, S. ^{[1
]}

Ramasamy, K. ^{[1
]}

Srinivasan, N. ^{[2
]}

Selvamurugan, N. ^{[1
,2
]}

机构：

[1] SRM Univ, Sch Bioengn, Dept Biotechnol, Kattankulathur 603203, Tamil Nadu, India

[2] Univ Madras Taramani, Dr ALM Post Grad Inst Basic Med Sci, Dept Endocrinol, Chennai 600113, Tamil Nadu, India

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2012年 / 12卷 / 01期

关键词：

Hydroxyapatite; Nanomaterials; Zinc; Antimicrobial Activity; TOTAL KNEE REPLACEMENT;

D O I：

10.1166/jnn.2012.5142

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The bone implants used in tissue repair are susceptible to infections caused by staphylococci, specifically Staphylococcus aureus. Hence, the development of better biological materials that provide antimicrobial activity in bone tissue engineering is required. The nanoparticles of hydroxyapatite (nHAp) and nHAp dopped with Zn (nHAp-Zn) were prepared by the wet chemical method and the ion exchange method, respectively. They were characterized using SEM, AFM, FTIR and XRD. The antibacterial activity of nHAp and nHAp-Zn was determined with Gram-negative and Gram-positive bacterial strains. The results indicated that nHAp alone was acting as an inert matrix and when substituted with Zn, it showed better antibacterial activity. The nHAp-Zn was found to be non-toxic to osteoprogenitor cells. Thus, due to the antimicrobial property of nHAp-Zn nanoparticles, we suggest that they would have potential applications towards bone tissue engineering.

引用

页码：167 / 172

页数：6

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