Effect of the preparation method of silver and gold nanoparticles on the photosensitizing properties of tetraphenylporphyrin-amphiphilic polymer-nanoparticle systems

被引：10
作者：
Aksenova, N. A. [1 ]
Savko, M. A. [1 ]
Uryupina, O. Ya. [2 ]
Roldugin, V. I. [2 ]
Timashev, P. S. [3 ]
Kuz'min, P. G. [4 ]
Shafeev, G. A. [4 ]
Solov'eva, A. B. [1 ]
机构：
[1] Semenov Inst Chem Phys, Moscow 117977, Russia
[2] Frumkin Inst Phys Chem & Electrochem, Moscow 199071, Russia
[3] Inst Laser & Informat Technol, Moscow 117971, Russia
[4] Prokhorov Gen Phys Inst, Wave Res Ctr, Moscow 119991, Russia
来源：
RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A | 2017年 / 91卷 / 01期
基金：
俄罗斯基础研究基金会; 俄罗斯科学基金会;
关键词：
porphyrin photosensitizers; nanoparticles; amphiphilic polymers; photooxidation of tryptophan; photodynamic therapy; PHOTODYNAMIC THERAPY;
D O I：
10.1134/S0036024417010022
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The ranges of concentrations of silver and gold nanoparticles in which the rate constants of the test for the photodynamic therapy (PDT) reaction of oxidation of tryptophan in an aqueous medium in the presence of photosensitizer remain virtually the same (without nanoparticles) are found. This testifies to the feasibility of causing additional photothermal damage on tumor cells by transforming the absorbed energy of electromagnetic radiation in the area of the plasmon resonances of the administered nanoparticles into heat energy in the PDT of tumors. Metal nanoparticles are obtained by photochemical and chemical methods, and by laser ablation. Tetraphenylporphyrin solubilized with Pluronic F127 (to attain its solubility in aqueous systems), the optical absorption band of which is close to the plasmon absorption bands of nanoparticles, is used as a photosensitizer.
引用
收藏
页码：124 / 129
页数：6
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