Microbiology - Antibiotic stops 'ping-pong' match

被引:14
作者
Brown, ED [1 ]
机构
[1] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON L8N 3Z5, Canada
关键词
D O I
10.1038/441293a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
As bacteria become resistant to existing drugs, there is a need for antibiotics with new modes of action. Such a compound has been found, and it works by binding to an intermediate in the catalytic cycle of its target.
引用
收藏
页码:293 / 294
页数:2
相关论文
共 8 条
  • [1] Bacterial fatty acid biosynthesis: Targets for antibacterial drug discovery
    Campbell, JW
    Cronan, JE
    [J]. ANNUAL REVIEW OF MICROBIOLOGY, 2001, 55 : 305 - 332
  • [2] Ford C. W., 2001, Current Drug Targets - Infectious Disorders, V1, P181, DOI 10.2174/1568005014606099
  • [3] Inhibitors of fatty acid synthesis as antimicrobial chemotherapeutics
    Heath, RJ
    White, SW
    Rock, CO
    [J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2002, 58 (06) : 695 - 703
  • [4] Daptomycin - a novel antibiotic against Gram-positive pathogens
    LaPlante, KL
    Rybak, MJ
    [J]. EXPERT OPINION ON PHARMACOTHERAPY, 2004, 5 (11) : 2321 - 2331
  • [5] The 1.3-Angstrom-resolution crystal structure of β-ketoacyl-acyl carrier protein synthase II from Streptococcus pneumoniae
    Price, AC
    Rock, CO
    White, SW
    [J]. JOURNAL OF BACTERIOLOGY, 2003, 185 (14) : 4136 - 4143
  • [6] Why is big Pharma getting out of antibacterial drug discovery?
    Projan, SJ
    [J]. CURRENT OPINION IN MICROBIOLOGY, 2003, 6 (05) : 427 - 430
  • [7] Platensimycin is a selective FabF inhibitor with potent antibiotic properties
    Wang, J
    Soisson, SM
    Young, K
    Shoop, W
    Kodali, S
    Galgoci, A
    Painter, R
    Parthasarathy, G
    Tang, YS
    Cummings, R
    Ha, S
    Dorso, K
    Motyl, M
    Jayasuriya, H
    Ondeyka, J
    Herath, K
    Zhang, CW
    Hernandez, L
    Allocco, J
    Basilio, A
    Tormo, JR
    Genilloud, O
    Vicente, F
    Pelaez, F
    Colwell, L
    Lee, SH
    Michael, B
    Felcetto, T
    Gill, C
    Silver, LL
    Hermes, JD
    Bartizal, K
    Barrett, J
    Schmatz, D
    Becker, JW
    Cully, D
    Singh, SB
    [J]. NATURE, 2006, 441 (7091) : 358 - 361
  • [8] Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus
    Weigel, LM
    Clewell, DB
    Gill, SR
    Clark, NC
    McDougal, LK
    Flannagan, SE
    Kolonay, JF
    Shetty, J
    Killgore, GE
    Tenover, FC
    [J]. SCIENCE, 2003, 302 (5650) : 1569 - 1571