GNPs-CS/KGM as Hemostatic First Aid Wound Dressing with Antibiotic Effect: In Vitro and In Vivo Study

被引：22

作者：

Fan, Li ^{[1
]}

Cheng, Chong ^{[1
]}

Qiao, Youbei ^{[1
]}

Li, Fei ^{[1
]}

Li, Wei ^{[1
]}

Wu, Hong ^{[1
]}

Ren, Bo ^{[2
]}

机构：

[1] Fourth Mil Med Univ, Sch Pharm, Dept Pharmaceut Chem & Anal, Xian 710032, Shaanxi, Peoples R China

[2] 302 Mil Hosp China, Dept Anesthesia, Beijing, Peoples R China

来源：

PLOS ONE | 2013年 / 8卷 / 07期

基金：

中国国家自然科学基金;

关键词：

CONDENSED STATE STRUCTURE; CHITOSAN; MICROSPHERES; REGENERATION; TRANSFUSION; ALGINATE; EFFICACY; COMPLEX;

D O I：

10.1371/journal.pone.0066890

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ideal wound dressing materials should create a good healing environment, with immediate hemostatic effects and antimicrobial activity. In this study, chitosan/konjac glucomannan (CS/KGM) films embedded with gentamicin-loaded poly(dex-GMA/AAc) nanoparticles (giving GNP-CS/KGM films) were prepared as novel wound dressings. The results revealed that the modified CS/KGM films could be used as effective wound dressings and had significant hemostatic effects. With their microporous structure, the films could effectively absorb water from blood and trap blood cells. The gentamicinloaded poly(dex-GMA/AAc) nanoparticles (GNPs) also further promoted blood clotting, with their favorable water uptake capacity. Thus, the GNP-CS/KGM films had wound healing and synergistic effects that helped to stop bleeding from injuries, and also showed good antibiotic abilities by addition of gentamicin to the NPs. These GNPCS/KGM films can be considered as promising novel biodegradable and biocompatible wound dressings with hemostatic capabilities and antibiotic effects for treatment of external bleeding injuries.

引用

页数：11

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