Humoral Human Lung Allograft Rejection by Tissue-Restricted Non-HLA Antibodies

被引：18

作者：

Fernandez, Ramiro ^{[1
,2
,3
]}

Chiu, Stephen ^{[1
,2
,3
]}

Raparia, Kirtee ^{[1
,2
,3
]}

Garcha, Puneet ^{[1
,2
,3
]}

Farver, Carol ^{[1
,2
,3
]}

Budev, Marie ^{[1
,2
,3
]}

Tambur, Anat R. ^{[1
,2
,3
]}

DeCamp, Malcolm M. ^{[1
,2
,3
]}

Budinger, Scott ^{[1
,2
,3
]}

Perlman, Harris ^{[1
,2
,3
]}

Mohanakumar, T. ^{[1
,2
,3
]}

Bharat, Ankit ^{[1
,2
,3
]}

机构：

[1] Northwester Univ Feinberg, Sch Med, Chicago, IL 60611 USA

[2] Cleveland Clin Fdn, 9500 Euclid Ave, Cleveland, OH 44195 USA

[3] Washington Univ, Sch Med, St Louis, MO 63130 USA

来源：

ANNALS OF THORACIC SURGERY | 2016年 / 102卷 / 04期

关键词：

SELF-ANTIGENS; TRANSPLANTATION; CELLS; DYSFUNCTION; PATHOLOGY;

D O I：

10.1016/j.athoracsur.2016.03.042

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A third of lung recipients have preexisting antibodies against nonhuman leukocyte self-antigens (nHAbs) present in the lung tissue. These nHAbs also form de novo in about 70% of patients within 3 years after transplantation. Both preexisting and de novo nHAbs can cause murine lung allograft dysfunction. However, their role in human transplantation remains unclear. We report hyperacute rejection after right lung transplant in a recipient with preexisting nHAbs. The recipient of the left lung from the same donor had an uneventful initial course, but de novo nHAbs developed at 3 weeks, leading to acute humoral rejection. Both patients were successfully treated with antibody-directed therapies. (C) 2016 by The Society of Thoracic Surgeons

引用

页码：E339 / E341

页数：3

共 10 条

[1] Pathology of pulmonary antibody-mediated rejection: 2012 update from the Pathology Council of the ISHLT [J].

Berry, Gerald ;

Burke, Margaret ;

Andersen, Claus ;

Angelini, Annalisa ;

Bruneval, Patrick ;

Calbrese, Fiorella ;

Fishbein, Michael C. ;

Goddard, Martin ;

Leone, Ornella ;

Maleszewski, Joseph ;

Marboe, Charles ;

Miller, Dylan ;

Neil, Desley ;

Padera, Robert ;

Rassi, Doris ;

Revell, Monica ;

Rice, Alexandra ;

Stewart, Susan ;

Yousem, Samuel A. .

JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2013, 32 (01) :14-21

[2] Respiratory Virus-Induced Dysregulation of T-Regulatory Cells Leads to Chronic Rejection [J].

Bharat, Ankit ;

Kuo, Elbert ;

Saini, Deepti ;

Steward, Nancy ;

Hachem, Ramsey ;

Trulock, Elbert P. ;

Patterson, G. Alexander ;

Meyers, Bryan F. ;

Mohanakumar, Thalachallour .

ANNALS OF THORACIC SURGERY, 2010, 90 (05) :1637-1644

[3] Antibodies to Self-Antigens Predispose to Primary Lung Allograft Dysfunction and Chronic Rejection [J].

Bharat, Ankit ;

Saini, Deepti ;

Steward, Nancy ;

Hachem, Ramsey ;

Trulock, Elbert P. ;

Patterson, Alexander ;

Meyers, Bryan F. ;

Mohanakumar, Thalachallour .

ANNALS OF THORACIC SURGERY, 2010, 90 (04) :1094-1100

[4] Clinical Risk Factors for Primary Graft Dysfunction after Lung Transplantation [J].

Diamond, Joshua M. ;

Lee, James C. ;

Kawut, Steven M. ;

Shah, Rupal J. ;

Localio, A. Russell ;

Bellamy, Scarlett L. ;

Lederer, David. J. ;

Cantu, Edward ;

Kohl, Benjamin A. ;

Lama, Vibha N. ;

Bhorade, Sangeeta M. ;

Crespo, Maria ;

Demissie, Ejigayehu ;

Sonett, Joshua ;

Wille, Keith ;

Orens, Jonathan ;

Shah, Ashish S. ;

Weinacker, Ann ;

Arcasoy, Selim ;

Shah, Pali D. ;

Wilkes, David S. ;

Ware, Lorraine B. ;

Palmer, Scott M. ;

Christie, Jason D. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2013, 187 (05) :527-534

[5] Differential processing of self-antigens by subsets of thymic stromal cells [J].

Guerder, Sylvie ;

Viret, Christophe ;

Luche, Herve ;

Ardouin, Laurence ;

Malissen, Bernard .

CURRENT OPINION IN IMMUNOLOGY, 2012, 24 (01) :99-104

[6] Antibodies to K-α 1 Tubulin and Collagen V Are Associated With Chronic Rejection After Lung Transplantation [J].

Hachem, R. R. ;

Tiriveedhi, V. ;

Patterson, G. A. ;

Aloush, A. ;

Trulock, E. P. ;

Mohanakumar, T. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2012, 12 (08) :2164-2171

[7]

Kheradmand F, 2012, EXPERT REV CLIN IMMU, V8, P285, DOI [10.1586/eci.12.7, 10.1586/ECI.12.7]

[8] The (re)emergence of B cells in organ transplantation [J].

Stegall, Mark D. ;

Raghavaiah, Suresh ;

Gloor, James M. .

CURRENT OPINION IN ORGAN TRANSPLANTATION, 2010, 15 (04) :451-455

[9] Immune Response to Tissue-Restricted Self-Antigens Induces Airway Inflammation and Fibrosis Following Murine Lung Transplantation [J].

Subramanian, V. ;

Ramachandran, S. ;

Banan, B. ;

Bharat, A. ;

Wang, X. ;

Benshoff, N. ;

Kreisel, D. ;

Gelman, A. E. ;

Mohanakumar, T. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2014, 14 (10) :2359-2366

[10] Anti-type V collagen lymphocytes that express IL-17 and IL-23 induce rejection pathology in fresh and well-healed lung transplants [J].

Yoshida, S ;

Haque, A ;

Mizobuchi, T ;

Iwata, T ;

Chiyo, M ;

Webb, TJ ;

Baldridge, LA ;

Heidler, KM ;

Cummings, OW ;

Fujisawa, T ;

Blum, JS ;

Brand, DD ;

Wilkes, DS .

AMERICAN JOURNAL OF TRANSPLANTATION, 2006, 6 (04) :724-735

← 1 →